正常妊娠和子痫前期妊娠中母体血清不对称二甲基精氨酸水平
Maternal serum levels of asymmetric dimethylarginine in normal and preeclamptic pregnancies.
作者信息
Selanno Johan Frangky, Riu Deviana Soraya, Tessy Telly, Chalid Maisuri Tajuddin, Pelupessy Nugraha Utama, Hartono Eddy
机构信息
Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
出版信息
Gynecol Endocrinol. 2020 Aug;36(8):702-704. doi: 10.1080/09513590.2019.1707793. Epub 2020 Mar 4.
The study aims to investigate maternal serum levels of asymmetric dimethylarginine (ADMA) in preeclampsia. Serum samples were collected from 57 women with preeclamptic pregnancies and 30 women with normal pregnancies during the third trimester. ADMA levels were measured with the ELISA method. ADMA levels in preeclamptic pregnancies were significantly higher when compared with normal pregnancies (2.35 ± 3.20 nmol/l versus 0.35 ± 0.10 nmol/l; < .05). ADMA levels show a significant positive correlation with systolic and diastolic pressure, urea, and creatinine but a negative correlation with proteinuria. ADMA levels have a significant strong correlation with PE. ADMA levels are significantly higher in preeclamptic pregnancy compared with normal pregnancy.
该研究旨在调查子痫前期孕妇血清中不对称二甲基精氨酸（ADMA）的水平。在孕晚期，从57例子痫前期孕妇和30例正常孕妇中采集血清样本。采用酶联免疫吸附测定（ELISA）法测量ADMA水平。与正常妊娠相比，子痫前期妊娠的ADMA水平显著更高（2.35±3.20纳摩尔/升对0.35±0.10纳摩尔/升；P<0.05）。ADMA水平与收缩压、舒张压、尿素和肌酐呈显著正相关，但与蛋白尿呈负相关。ADMA水平与子痫前期有显著的强相关性。与正常妊娠相比，子痫前期妊娠的ADMA水平显著更高。
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