Rakesh Divyangana, Fernando Kavisha B, Mansour L Sina
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health.
Department of Biomedical Engineering, University of Melbourne.
J Neurophysiol. 2020 Apr 1;123(4):1279-1282. doi: 10.1152/jn.00039.2020. Epub 2020 Mar 4.
Nonpathological aging is associated with significant cognitive deficits. Thus, the underlying neurobiology of aging-associated cognitive decline warrants investigation. In a recent study, Chong et al. (Chong JSX, Ng KK, Tandi J, Wang C, Poh J-H, Lo JC, Chee MWL, Zhou JH. 39: 5534-5550, 2019) provided insights into the association between cognitive decline and the loss of functional specialization in the brains of older adults. Here, we introduce the novel graph theoretical approach utilized and discuss the significance of their findings and broader implications on aging. We also provide alternate perspectives of their findings and suggest directions for future work.
非病理性衰老与显著的认知缺陷相关。因此，与衰老相关的认知衰退的潜在神经生物学值得研究。在最近的一项研究中，Chong等人（Chong JSX、Ng KK、Tandi J、Wang C、Poh J-H、Lo JC、Chee MWL、Zhou JH。39: 5534 - 5550, 2019）深入探讨了老年人认知衰退与大脑功能特化丧失之间的关联。在此，我们介绍所采用的新颖图论方法，并讨论他们研究结果的意义以及对衰老更广泛的影响。我们还提供了对他们研究结果的不同观点，并为未来的工作提出方向。
