Dukova-Peneva P, Penev M, Razsolkov M
Vutr Boles. 1988;27(4):81-5.
32 healthy persons, 12 men and 20 women, 19 to 48 years of age, were examined in the three positions--recumbent, sitting and erect. Blood was taken by venepuncture after 15 minutes stay in the position. The analyses were carried out with the discrete analyzer "PA-1000", flame photometer, chlorine titrator "Radiometer" and osmometer "Knauer". The statistical assessment was performed by the pair analysis. The changing of the body position from recumbent to sitting and to erect leads to a significant increase of the concentrations of the total protein and albumin which cannot pass through the capillary endothelial barrier following the changes in the hydrostatic and filtration pressure. The capillary endothelial barrier is permeable for the low-molecular compounds whose concentrations change insignificantly. Cholesterol and triglycerides are an exception since they are bound to nonfilterable lipoprotein complexes. Reliable increase of creatinine is found only in the women examined. Calcium which in the serum is protein-bound also increases significantly. A significant increase is found also of the activity of the enzymes creatine kinase, alkaline phosphatase and gamma GTP. The changes of the activity of the enzymes AsAT, AlAT, LDH and hydroxybutyrate dehydrogenase are insignificant.
对32名健康人进行了检查，其中男性12名，女性20名，年龄在19至48岁之间。让他们分别处于卧位、坐位和直立位这三种姿势下进行检查。在每种姿势保持15分钟后通过静脉穿刺采血。分析使用“PA - 1000”离散分析仪、火焰光度计、“Radiometer”氯滴定仪和“Knauer”渗透压计进行。统计评估采用配对分析。身体姿势从卧位变为坐位再变为直立位会导致总蛋白和白蛋白浓度显著增加，这些蛋白不能透过毛细血管内皮屏障，这是由于流体静压和滤过压发生了变化。毛细血管内皮屏障对低分子化合物是可渗透的，其浓度变化不显著。胆固醇和甘油三酯是例外，因为它们与不可滤过的脂蛋白复合物结合。仅在接受检查的女性中发现肌酐有可靠的增加。血清中与蛋白结合的钙也显著增加。肌酸激酶、碱性磷酸酶和γ - GTP的酶活性也有显著增加。谷草转氨酶、谷丙转氨酶、乳酸脱氢酶和羟丁酸脱氢酶的活性变化不显著。
