Nascente Lígia Moschen de Paula, Grandi Carlos, Aragon Davi Casale, Cardoso Viviane Cunha
Department of Pediatrics, Ribeirão Preto Medical School, Universidade de São Paulo - São Paulo (SP), Brazil.
Department of Pediatrics, Sardá Maternity Hospital, Universidad de Buenos Aires - Buenos Aires, Argentina.
Rev Bras Epidemiol. 2020 Feb 21;23:e200004. doi: 10.1590/1980-549720200004. eCollection 2020.
Epidemiological studies have shown associations between placental measurements and perinatal and later life outcomes.
To report placental measurements and evaluate their association with birth weight in a Brazilian birth cohort.
Retrospective cohort study with 958 mothers, placentas, and newborns delivered at the Ribeirão Preto Medical School Hospital, Universidade de São Paulo, Brazil, in 2010 and 2011. The information was collected from interviews, medical records, and pathology reports. The placental measurements were: weight, largest and smallest diameters, eccentricity, thickness, shape, area, and birth weight/placental weight and placental weight/birth weight ratios. We analyzed the associations between birth weight and placental measurements using multiple linear regression.
Placental weight alone accounted for 48% of birth weight variability (p < 0.001), whereas placental measurements combined (placental weight, largest and smallest diameters, and thickness) were responsible for 50% (p < 0.001). When adjusted for maternal and neonatal characteristics, placental measurements explained 74% of birth weight variability (p < 0.001).
Placental measurements are powerful independent predictors of birth weight. Placental weight is the most predictive of them, followed by the smallest diameter.
流行病学研究表明胎盘测量值与围产期及后期生活结局之间存在关联。
报告巴西一个出生队列中的胎盘测量值，并评估其与出生体重的关联。
对2010年和2011年在巴西圣保罗大学里贝朗普雷图医学院医院分娩的958名母亲、胎盘和新生儿进行回顾性队列研究。信息通过访谈、病历和病理报告收集。胎盘测量值包括：重量、最大和最小直径、偏心度、厚度、形状、面积以及出生体重/胎盘重量和胎盘重量/出生体重比值。我们使用多元线性回归分析出生体重与胎盘测量值之间的关联。
仅胎盘重量就占出生体重变异性的48%（p < 0.001），而综合胎盘测量值（胎盘重量、最大和最小直径以及厚度）占50%（p < 0.001）。在对母亲和新生儿特征进行调整后，胎盘测量值解释了74%的出生体重变异性（p < 0.001）。
胎盘测量值是出生体重的有力独立预测因素。胎盘重量是其中最具预测性的，其次是最小直径。
