Dimov D M, Dacheva V, Dimov D P, Shishmanov D, Daskalov T
Vutr Boles. 1988;27(5):66-9.
Critical conditions had been established in 21 (23.1%) of 91 patients with systemic connective tissue diseases for a 12 year period: renal failure (most often), sepsis, pericarditis with cardiac tamponade, hemorrhagic diathesis, terminal arteritis with gangrene, gastrointestinal perforations with peritonitis, etc. The corticosteroids applied in high doses and predominantly parenterally and the immunosuppressors are the main drugs used in the treatment of these conditions. Plasmapheresis when possible is a useful supplement. The prognosis of the acute critical conditions depends mainly on the affected organ (more favorable in pericarditis with tamponade and unfavorable in renal failure and gastrointestinal perforations with peritonitis (and on the basic disease) more optimistic in systemic lupus erythematodes and very pessimistic in nodal periarteritis and other allergic vasculitis).
在91例系统性结缔组织病患者中，12年间有21例（23.1%）出现危急情况：最常见的是肾衰竭，还有败血症、心包炎伴心脏压塞、出血素质、终末期动脉炎伴坏疽、胃肠道穿孔伴腹膜炎等。大剂量应用且主要经胃肠外途径给予的皮质类固醇和免疫抑制剂是治疗这些病症的主要药物。如有可能，血浆置换是一种有用的辅助治疗方法。急性危急情况的预后主要取决于受累器官（心包炎伴压塞的预后较有利，而肾衰竭和胃肠道穿孔伴腹膜炎的预后不利）（以及基础疾病，系统性红斑狼疮的预后较乐观，结节性动脉周围炎和其他过敏性血管炎的预后非常悲观）。
