壮丽酰胺是一种新型有效的哺乳动物α-淀粉酶抑制剂。
Magnificamide Is a New Effective Mammalian α-Amylase Inhibitor.
作者信息
Sintsova O V, Leychenko E V, Gladkikh I N, Kalinovskii A P, Monastyrnaya M M, Kozlovskaya E P
机构信息
Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 690022, Vladivostok, Russia.
School of Natural Sciences, Far Eastern Federal University, 690091, Vladivostok, Russia.
出版信息
Dokl Biochem Biophys. 2019 Nov;489(1):385-387. doi: 10.1134/S1607672919060097. Epub 2020 Mar 4.
Recombinant analogue of the sea anemone Heteractismagnifica peptide was obtained, and the kinetic parameters of its interaction with mammalian α-amylases were determined. Magnificamide inhibits α-amylases significantly stronger than the medical drug acarbose (Precose or Glucobay). Magnificamide is assumed to find application as a drug for prevention and treatment of metabolic disorders and type 2 diabetes mellitus.
获得了海葵壮丽海葵肽的重组类似物，并测定了其与哺乳动物α-淀粉酶相互作用的动力学参数。壮丽酰胺对α-淀粉酶的抑制作用明显强于药物阿卡波糖（拜糖平或卡博平）。预计壮丽酰胺可作为预防和治疗代谢紊乱及2型糖尿病的药物。
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