Infertility Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via M. Fanti, 6, 20122, Milan, Italy.
Gynaecologic Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
J Assist Reprod Genet. 2020 May;37(5):1213-1216. doi: 10.1007/s10815-020-01733-6. Epub 2020 Mar 4.
Borderline ovarian tumors (BOTs) commonly occur during reproductive years. Given the good prognosis, fertility-sparing surgery can be considered in young women wishing to preserve their fertility. However, conservative management exposes patients to the risk of recurrence. In these cases, the new surgery may be radical (completing the removal of both adnexa) or, when conservative, it may be associated with relevant damage to the ovarian reserve. In this study, we report on two women who decided to perform ovarian hyper-stimulation and oocyte cryostorage at the time of the diagnosis of recurrence, but before undergoing the new surgery. They both obtained a satisfactory number of oocytes, the retrieval was unremarkable, and no main detrimental effects on the ovarian lesions were noticed. These two cases suggest that ovarian hyper-stimulation and oocyte retrieval before planned surgery for BOT recurrence is a feasible option.
交界性卵巢肿瘤(BOT)常见于生育期。鉴于其良好的预后,对于有生育要求的年轻患者,可考虑保留生育功能的手术。然而,保守治疗会使患者面临复发的风险。在这些情况下,新的手术可能是根治性的(完全切除附件),或者当保守治疗时,可能会对卵巢储备功能造成相关损害。在本研究中,我们报告了两名在诊断复发后、但在新手术前选择进行卵巢超刺激和卵母细胞冷冻保存的患者。她们均获得了满意数量的卵母细胞,取卵过程无明显异常,且卵巢病变未出现主要的不良影响。这两个案例提示,对于交界性卵巢肿瘤复发的计划性手术前进行卵巢超刺激和卵母细胞采集是一种可行的选择。