Universitat Rovira i Virgili, Departament de Quı́mica Fı́sica i Inorgànica, C/Marcel·lı́ Domingo 1, 43007 Tarragona, Spain.
J Org Chem. 2020 Apr 3;85(7):4730-4739. doi: 10.1021/acs.joc.9b03508. Epub 2020 Mar 13.
We have identified a successful family of simple P-stereogenic -phosphine-phosphite ligands for the Rh-catalyzed asymmetric hydrogenation of olefins. These catalysts show excellent enantiocontrol for α-dehydroamino acid derivatives and α-enamides (ee's up to >99%) and promising results for the more challenging β-analogues (ee's up to 80%). The usefulness of these catalytic systems was further demonstrated with the synthesis of several valuable precursors for pharmacologically active compounds, with ee's at least as high as the best ones reported previously (up to >99%).
我们已经确定了一组成功的简单 P-手性膦-亚磷酸配体，用于 Rh 催化的烯烃不对称氢化。这些催化剂对α-去氢氨基酸衍生物和α-烯酰胺显示出优异的对映体控制（ee 值高达>99%），并且对更具挑战性的β类似物也有很好的结果（ee 值高达 80%）。这些催化体系的有用性还通过合成几种具有药理活性化合物的有价值的前体进一步证明，ee 值至少与以前报道的最好值一样高（高达>99%）。
