角蛋白结构类型与人类疾病之间的界面。
The Interface between Keratin Structurotype and Human Disease.
机构信息
Department of Dermatology, Yale University, New Haven, CT 06520, USA.
Department of Dermatology, Yale University, New Haven, CT 06520, USA; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
出版信息
Structure. 2020 Mar 3;28(3):271-273. doi: 10.1016/j.str.2020.02.002.
Abstract
In this issue of Structure, Coulombe and coworkers (Lee et al., 2020) present the crystal structure of the keratin 5/14 2B heterodimeric complex containing the keratin 14 substitution C367A. The authors identify a 2B-2B contact interface important to the elongation of mature keratin 5/14 filaments.
摘要
在本期《结构》中，Coulombe 及其同事（Lee 等人，2020）报告了含有角蛋白 14 突变 C367A 的角蛋白 5/14 2B 异二聚体复合物的晶体结构。作者确定了一个对成熟角蛋白 5/14 纤维伸长很重要的 2B-2B 接触界面。
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