CBP/Shank3 如何保护 Rap 和 H-Ras

How CBP/Shank3 Guards Rap and H-Ras.

机构信息

Department of Pharmacology, University of California at Davis, 451 Health Sciences Dr., Davis, CA 95616, USA.

出版信息

Structure. 2020 Mar 3;28(3):274-276. doi: 10.1016/j.str.2020.02.003.

DOI:10.1016/j.str.2020.02.003

Abstract

In this issue of Structure, Cai et al. (2020) describe crystal structures of the postsynaptic protein Shank3, a homolog of cortactin binding protein 1 (CBP1), in complex with small G proteins Rap1 and H-Ras. Functional studies suggest that binding of Ras and Rap to Shank3 is modulated by synaptic plasticity.

摘要

在本期《结构》杂志中，蔡等人（2020 年）描述了突触后蛋白 Shank3 与小 G 蛋白 Rap1 和 H-Ras 复合物的晶体结构，Shank3 是细胞皮层结合蛋白 1（CBP1）的同源物。功能研究表明，Ras 和 Rap 与 Shank3 的结合受突触可塑性的调节。