School of Medical and Health Science, Edith Cowan University, Perth, W.A., Australia.
Western Australian Bone Research Collaboration, Perth, W.A., Australia.
J Musculoskelet Neuronal Interact. 2020 Mar 3;20(1):27-52.
To describe peripheral long bone material and structural differences in youth at risk of secondary osteoporosis across disease-specific profiles.
Upper- and lower limbs of children and adolescents were scanned at 4% distal and 66% mid-shaft sites using peripheral Quantitative Computed Tomography sub-categorised as (1) increased risk of secondary osteoporosis (neuromuscular disorders; chronic diseases; endocrine diseases; inborn errors of metabolism; iatrogenic conditions), (2) low motor competence and (3) non-affected controls.
Children with disease-specific profiles showed a range of bone deficits compared to the control group with these predominantly indicated for neuromuscular disorders, chronic diseases and low motor competence. Deficits between upper arm and lower leg long bone parameters were different for disease-specific profiles compared to the control group. Endocortical radius, muscle area, and mid-cortical ring density were not significantly different for any disease-specific profile compared to the control group for any bone sites.
Neuromuscular disorders, chronic diseases and low motor competence have a strong correlation to bone health for appendicular bone parameters in youth, suggesting a critical mechanical loading influence which may differ specific to disease profile. As mechanical loading effects are observed in regional bone analyses, targeted exercise interventions to improve bone strength should be implemented to examine if this is effective in reducing the risk of secondary osteoporosis in youth.
描述具有不同特定疾病特征的继发性骨质疏松症高危青少年四肢长骨的材料和结构差异。
采用外周定量计算机断层扫描技术，对儿童和青少年四肢的 4%远端和 66%中段部位进行扫描，扫描结果分为（1）继发性骨质疏松症风险增加（神经肌肉疾病；慢性疾病；内分泌疾病；先天性代谢紊乱；医源性疾病）、（2）运动能力低下和（3）非患病对照组。
与对照组相比，具有特定疾病特征的儿童表现出一系列骨骼缺陷，这些缺陷主要与神经肌肉疾病、慢性疾病和运动能力低下有关。与对照组相比，不同疾病特征的上肢和下肢长骨参数之间存在差异。与对照组相比，任何疾病特征在任何骨骼部位的内皮质半径、肌肉面积和中皮质环密度均无显著差异。
神经肌肉疾病、慢性疾病和运动能力低下与青少年四肢长骨参数的骨骼健康密切相关，这表明机械负荷的影响可能因疾病特征而异。由于在区域性骨分析中观察到了机械加载效应，因此应实施有针对性的运动干预措施来改善骨强度，以检验其是否能有效降低青少年继发性骨质疏松症的风险。
