淋巴管浸润与浅表性食管癌淋巴结转移和预后的关系：系统评价和荟萃分析。
Relationship of lymphovascular invasion with lymph node metastasis and prognosis in superficial esophageal carcinoma: systematic review and meta-analysis.
机构信息
Department of Radiation Oncology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Department of Thoracic Surgery, Huashan Hospital, Fudan University, Shanghai, China.
出版信息
BMC Cancer. 2020 Mar 4;20(1):176. doi: 10.1186/s12885-020-6656-3.
BACKGROUND
The development of tumor cells inside the lymphatics or blood vessels is known as lymphovascular invasion (LVI). The correlation between LVI, lymph node metastasis (LNM), and the diagnosis of superficial esophageal carcinoma (SEC) remains unclear.
METHODS
We searched Embase, PubMed, Web of Science, and Cochrane Library databases for prospective articles to better understand the relationship between LVI, LNM, and SEC diagnosis.
RESULTS
We included 23 articles containing data for 4749 patients (range: 54-598) in our meta-analysis. The hazard ratio between LVI and overall survival (OS) was 1.85 with 95% confidence interval (CI) (1.10-3.11, P = 0.02). LNM rate was higher in SEC patients with LVI than SEC patients without LVI (univariate: OR = 4.94, 95% CI: 3.74-6.53, P < 0.0001; multivariate: OR = 5.72, 95%CI: 4.38-7.4, P < 0.0001). No obvious publication was found.
CONCLUSIONS
The results indicate that LVI plays a dominant role in the prognosis of LNM in SEC and in the prognostic prediction for SEC.
背景
淋巴管或血管内的肿瘤细胞发展称为淋巴血管侵犯（LVI）。LVI、淋巴结转移（LNM）与浅表食管癌（SEC）诊断之间的相关性尚不清楚。
方法
我们检索了 Embase、PubMed、Web of Science 和 Cochrane Library 数据库中的前瞻性文章，以更好地了解 LVI、LNM 和 SEC 诊断之间的关系。
结果
我们的荟萃分析纳入了 23 项包含 4749 名患者（范围：54-598）数据的文章。LVI 与总生存期（OS）之间的风险比为 1.85，95%置信区间（CI）为 1.10-3.11，P=0.02。有 LVI 的 SEC 患者的 LNM 发生率高于无 LVI 的 SEC 患者（单变量：OR=4.94，95%CI：3.74-6.53，P<0.0001；多变量：OR=5.72，95%CI：4.38-7.4，P<0.0001）。未发现明显的发表偏倚。
结论
结果表明，LVI 在 SEC 中 LNM 的预后和 SEC 的预后预测中起主导作用。
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