Ru Qin, Li Chao Ying, Li Yi
Wuhan Institute of Biomedical Sciences,Jianghan University,Wuhan 430056,China.
Department of Psychiatry,Wuhan Mental Health Center,Wuhan 430012,China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2020 Feb 28;42(1):108-116. doi: 10.3881/j.issn.1000-503X.10972.
G protein-gated inward rectifier potassium(GIRK)channels are widely distributed in the central nervous system and play important roles in maintaining the resting membrane potential of neurons,adjusting neuronal excitability,and regulating the release of neurotransmitter.Studies have shown that addictive behavior is closely related to the expression and activity of the GIRK channels in the brain reward system and the GIRK channels may be a potential target for addiction treatment.This article summarizes the recent research advances in GIRK channels in terms of structure,intracranial tissue distribution,and especially substance addiction.
G蛋白门控内向整流钾通道（GIRK通道）广泛分布于中枢神经系统，在维持神经元静息膜电位、调节神经元兴奋性以及调控神经递质释放等方面发挥着重要作用。研究表明，成瘾行为与大脑奖赏系统中GIRK通道的表达和活性密切相关，GIRK通道可能是成瘾治疗的一个潜在靶点。本文就GIRK通道的结构、颅内组织分布，尤其是物质成瘾方面的最新研究进展进行综述。
