丙二胺系列聚胺类似物抑制前列腺肿瘤细胞生长并激活聚胺分解代谢途径。
Polyamine Analogues of Propanediamine Series Inhibit Prostate Tumor Cell Growth and Activate the Polyamine Catabolic Pathway.
机构信息
Astrakhan State Medical University Health Ministry of Russian Federation, Astrakhan, Russian Federation.
Peoples' Friendship University of Russia (RUDN University), Moscow, Russian Federation.
出版信息
Anticancer Res. 2020 Mar;40(3):1437-1441. doi: 10.21873/anticanres.14085.
BACKGROUND/AIM: Polyamines are important for the growth of eukaryotic cells. At high levels, they promote proliferation, invasion and migration of tumour cells. Polyamine metabolism is an important new target for anticancer therapy. Some polyamine analogues can have an inhibitory effect on tumour cells. The aim of this study was to explore the potential of certain butylated derivatives of propanediamine for prostate cancer chemotherapy.
MATERIALS AND METHODS
Human prostate cancer cells, LNCaP, were used for the evaluation of the antiproliferative activity of polyamine analogs and their influence on spermine oxidase.
RESULTS
Tetrabutyl propanediamine and two new polyamine analogues inhibited the growth of LNCaP cells. At the same time, a strong activation of spermine oxidase was observed.
CONCLUSION
The investigated compounds demonstrated their potential value in the therapy of human prostate cancer. Their effect might be attributed to the activation of the polyamine catabolic pathway.
背景/目的：多胺对真核细胞的生长很重要。在高浓度下，它们促进肿瘤细胞的增殖、侵袭和迁移。多胺代谢是癌症治疗的一个新的重要靶点。一些多胺类似物对肿瘤细胞有抑制作用。本研究旨在探讨某些丙二胺的丁基衍生物在前列腺癌化疗中的潜在应用。
材料和方法
用人前列腺癌细胞 LNCaP 评估多胺类似物的抗增殖活性及其对精脒氧化酶的影响。
结果
四丁基丙二胺和两种新的多胺类似物抑制了 LNCaP 细胞的生长。同时，观察到精脒氧化酶的强烈激活。
结论
研究的化合物在人类前列腺癌的治疗中表现出了潜在的价值。它们的作用可能归因于多胺分解代谢途径的激活。
Zotero 插件