胃液碳水化合物抗原 72.4（Ca 72.4）升高是胃癌患者生存不良的独立预后因素。
Elevated Gastric Juice Carbohydrate Antigen 72.4 (Ca 72.4) Is an Independent Prognostic Factor of Poor Survival for Gastric Cancer Patients.
机构信息
Department of Medical and Surgical Sciences and Translational Medicine, Faculty of Medicine and Psychology, University "Sapienza", St. Andrea Hospital, Rome, Italy
Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, University "Sapienza", St. Andrea Hospital, Rome, Italy.
出版信息
Anticancer Res. 2020 Mar;40(3):1691-1695. doi: 10.21873/anticanres.14121.
BACKGROUND/AIM: As of 2020, carbohydrate antigen 72.4 (Ca 72.4) has been rarely investigated in the gastric juice (GJ) of patients with gastric cancer (GC). Our aim was to analyze the significance and role of this tumor antigen in the GJ of our GC population.
PATIENTS AND METHODS
Between April 2012 and July 2013, 37 patients with operable GC were prospectively investigated to determine the GJ Ca 72.4 levels before surgical manipulation.
RESULTS
GJ Ca 72.4 ≥6.49 ng/ml strongly correlated with the traditional categories of aggressive cancer (advanced tumor depth and stage, lymph node invasion and metastatic lymphatic ratio, indication to adjuvant treatment). It also associated with shorter survival (p=0.049) and is, thus, suggested as an independent factor of poor prognosis in GC patients (p=0.047).
CONCLUSION
The GJ Ca 72.4 parameter should be considered an indicator of an aggressive tumor phenotype and should be used in the prognostic assessment of GC patients.
背景/目的：截至 2020 年，癌抗原 72.4（Ca 72.4）在胃癌（GC）患者的胃液（GJ）中很少被研究。我们的目的是分析这种肿瘤抗原在我们的 GC 人群的 GJ 中的意义和作用。
患者和方法
2012 年 4 月至 2013 年 7 月，前瞻性调查了 37 例可手术的 GC 患者，以确定手术前 GJ Ca 72.4 水平。
结果
GJ Ca 72.4≥6.49ng/ml 与传统的侵袭性癌症类别（肿瘤深度和分期较晚、淋巴结浸润和转移性淋巴结比例、辅助治疗指征）强烈相关。它还与较短的生存时间相关（p=0.049），因此被认为是 GC 患者预后不良的独立因素（p=0.047）。
结论
GJ Ca 72.4 参数应被视为侵袭性肿瘤表型的指标，并应用于 GC 患者的预后评估。
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