Jiao Dan, Guo Feng, Yue Meng, Tian Zhen
Department of Ultrasound, China-Japan Union Hospital of Jilin University.
Department of Colorecal and Anal Surgery, The First Hospital of Jilin University.
Int Heart J. 2020 Mar 28;61(2):332-337. doi: 10.1536/ihj.19-489. Epub 2020 Mar 4.
Increased arterial stiffness is strongly associated with cardiovascular morbidity and mortality in dialysis patients. Ischemia-modified albumin (IMA) is a useful biomarker of cardiac ischemia. This study was aimed to explore the association between IMA and arterial stiffness in hemodialysis patients. An observational study was conducted with 120 hemodialysis patients. Clinical data and laboratory characteristics were collected. Arterial stiffness was evaluated by brachial-ankle pulse wave velocity (baPWV). Hemodialysis patients had extensive arterial stiffness and high levels of IMA. Comparing to hemodialysis patients with normal baPWV, those with high baPWV had significantly higher levels of IMA (93.7 ± 8.6 versus 73.1 ± 10.7 Ku/L, P = 0.027). The multiple linear regression analysis showed that IMA was significantly associated with arterial stiffness in hemodialysis patients (β = 0.43, P < 0.001). Moreover, IMA, with a threshold value of 90.4 Ku/L, provided 77.4% sensitivity and 86.6% specificity for predicting arterial stiffness. Hemodialysis patients with arterial stiffness had high levels of IMA. IMA was a good predictive marker of arterial stiffness for hemodialysis patients.
动脉僵硬度增加与透析患者的心血管发病率和死亡率密切相关。缺血修饰白蛋白（IMA）是心脏缺血的一种有用生物标志物。本研究旨在探讨血液透析患者中IMA与动脉僵硬度之间的关联。对120例血液透析患者进行了一项观察性研究。收集了临床数据和实验室特征。通过臂踝脉搏波速度（baPWV）评估动脉僵硬度。血液透析患者存在广泛的动脉僵硬度且IMA水平较高。与baPWV正常的血液透析患者相比，baPWV高的患者IMA水平显著更高（93.7±8.6对73.1±10.7 Ku/L，P = 0.027）。多元线性回归分析表明，IMA与血液透析患者的动脉僵硬度显著相关（β = 0.43，P < 0.001）。此外，IMA阈值为90.4 Ku/L时，预测动脉僵硬度的敏感性为77.4%，特异性为86.6%。有动脉僵硬度的血液透析患者IMA水平较高。IMA是血液透析患者动脉僵硬度的良好预测指标。
