Section of Neurology, Department of Medicine, University of Perugia, Perugia, Italy.
Mass Spectrometry Centre (CISM), Department of Health Sciences, University of Florence, Florence, Italy.
Front Immunol. 2020 Feb 18;11:157. doi: 10.3389/fimmu.2020.00157. eCollection 2020.
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) that is associated with demyelination and neuronal loss. Over recent years, the immunological and neuronal effects of tryptophan (Trp) metabolites have been largely investigated, leading to the hypothesis that these compounds and the related enzymes are possibly involved in the pathophysiology of MS. Specifically, the kynurenine pathway of Trp metabolism is responsible for the synthesis of intermediate products with potential immunological and neuronal effects. More recently, Trp metabolites, originating also from the host microbiome, have been identified in MS, and it has been shown that they are differently regulated in MS patients. Here, we sought to discuss whether, in MS patients, a specific urinary signature of host/microbiome Trp metabolism can be potentially identified so as to select novel biomarkers and guide toward the identification of specific metabolic pathways as drug targets in MS.
多发性硬化症（MS）是一种中枢神经系统（CNS）自身免疫性疾病，与脱髓鞘和神经元丢失有关。近年来，色氨酸（Trp）代谢物的免疫和神经元作用已得到广泛研究，这导致了这样一种假说，即这些化合物和相关酶可能参与 MS 的病理生理学。具体来说，Trp 代谢的犬尿氨酸途径负责合成具有潜在免疫和神经元作用的中间产物。最近，MS 中也鉴定出了源自宿主微生物组的 Trp 代谢物，并且已经表明它们在 MS 患者中的调节方式不同。在这里，我们试图探讨是否可以在 MS 患者中确定宿主/微生物组 Trp 代谢的特定尿生物标志物特征，以便选择新的生物标志物并指导确定 MS 中的特定代谢途径作为药物靶点。
