从草莓舌龈炎到腭穿孔：肉芽肿性多血管炎的口腔黏膜病变的临床病理谱。
From strawberry gingivitis to palatal perforation: The clinicopathological spectrum of oral mucosal lesions in granulomatosis with polyangiitis.
机构信息
Department of Dermatology, Medical School, University of São Paulo, São Paulo, Brazil.
Department of Pathology, Dental School, University of São Paulo, São Paulo, Brazil.
出版信息
J Oral Pathol Med. 2020 May;49(5):443-449. doi: 10.1111/jop.13008. Epub 2020 Mar 17.
BACKGROUND
Reports of oral manifestations of granulomatosis with polyangiitis (GPA) usually refer to single-case reports; "strawberry gingivitis" has been increasingly reported.
OBJECTIVE
To study the clinicopathological findings of four patients in which the diagnosis of GPA was suspected from the observation of their oral lesions and compare these to existent data.
METHODS
Retrospective study of a case series.
RESULTS
One patient presented typical "strawberry gingivitis" with localized disease and negative ANCA results. Two patients presented rapidly growing oral ulcers associated with systemic compromise and high ANCA levels. One patient presented with a chronic granulomatous lesion that leaded to palatal perforation.
CONCLUSION
Oral manifestations of GPA may vary from rapidly evolving lesions in acutely ill patients to chronic and locally destructive lesions in slowing developing disease. These differences are also evident in the histopathological findings.
背景
肉芽肿性多血管炎（GPA）口腔表现的报道通常指的是个案报告；“草莓牙龈炎”的报道越来越多。
目的
研究从口腔病变观察到 GPA 疑似诊断的 4 例患者的临床病理表现，并与现有数据进行比较。
方法
病例系列回顾性研究。
结果
1 例患者表现为典型的“草莓牙龈炎”，局部病变，ANCA 结果阴性。2 例患者表现为快速生长的口腔溃疡，伴有全身并发症和高 ANCA 水平。1 例患者表现为慢性肉芽肿性病变，导致腭穿孔。
结论
GPA 的口腔表现可以从急性发病患者中迅速进展的病变到缓慢发展疾病中的慢性和局部破坏性病变。这些差异在组织病理学发现中也很明显。
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