von Bülow M, Lauff V, Lehnert H, Nägele-Wöhrle B, Junginger T
Klinik und Poliklinik für Allgemein- und Abdominalchirurgie, Universitätsklinikums Mainz, BRD.
Acta Med Austriaca. 1988;15(4):115-6.
We investigated whether preoperative injection of 123-Jod-MIBG might be useful for intraoperative staging of chromaffine tumor cells. This was performed in a 46 year old patient in whome the diagnosis of a malignant pheochromocytoma had been established by 123-Jod-MIBG image and in catacholamine secretion. The rational for intraoperative staging of this patient was a discrepancy between computer tomography (CT) and the radio nuclide imagine. Intraoperative the tumor mass was identified with an activity of 10 x 10(4) Imp/sec as compared to normal tissue (15 x 10(2). A lymph node metastasis was found to be identified only by prior MIBG imagine and not by CT scanning. We thus conclude that intraoperative employment of this single probe measurement method might help to identify chromaffine tumor cells that have not been located fully by CT.
我们研究了术前注射123-碘-间碘苄胍（123-Jod-MIBG）是否有助于嗜铬细胞瘤细胞的术中分期。这项研究在一名46岁患者中进行，该患者通过123-Jod-MIBG显像和儿茶酚胺分泌已确诊为恶性嗜铬细胞瘤。对该患者进行术中分期的原因是计算机断层扫描（CT）与放射性核素显像结果存在差异。术中发现肿瘤肿块的放射性活度为10×10⁴次/秒，而正常组织为15×10²次/秒。仅通过术前MIBG显像而非CT扫描发现了一处淋巴结转移。因此我们得出结论，术中采用这种单探头测量方法可能有助于识别CT未能完全定位的嗜铬细胞瘤细胞。
