Department of Physiology, Basic Medical College of Nanchang University, Nanchang 330006, China.
Department of Fourth Clinical Medicine, School of Medicine, Nanchang University, Nanchang 330006, China.
J Zhejiang Univ Sci B. 2020;21(3):204-217. doi: 10.1631/jzus.B1900425.
Microglia are important cells involved in the regulation of neuropathic pain (NPP) and morphine tolerance. Information on their plasticity and polarity has been elucidated after determining their physiological structure, but there is still much to learn about the role of this type of cell in NPP and morphine tolerance. Microglia mediate multiple functions in health and disease by controlling damage in the central nervous system (CNS) and endogenous immune responses to disease. Microglial activation can result in altered opioid system activity, and NPP is characterized by resistance to morphine. Here we investigate the regulatory mechanisms of microglia and review the potential of microglial inhibitors for modulating NPP and morphine tolerance. Targeted inhibition of glial activation is a clinically promising approach to the treatment of NPP and the prevention of morphine tolerance. Finally, we suggest directions for future research on microglial inhibitors.
小胶质细胞是参与神经病理性疼痛（NPP）和吗啡耐受调节的重要细胞。在确定其生理结构后，阐明了它们的可塑性和极性信息，但对于这种细胞在 NPP 和吗啡耐受中的作用，仍有许多需要了解。小胶质细胞通过控制中枢神经系统（CNS）的损伤和对疾病的内源性免疫反应来介导多种健康和疾病中的功能。小胶质细胞的激活可导致阿片系统活性改变，NPP 的特征是对吗啡的耐药性。在这里，我们研究了小胶质细胞的调节机制，并综述了小胶质细胞抑制剂调节 NPP 和吗啡耐受的潜力。靶向抑制神经胶质细胞的激活是治疗 NPP 和预防吗啡耐受的一种很有前途的临床方法。最后，我们为小胶质细胞抑制剂的未来研究提出了方向。
