Ludvik B, Niederle B, Roka R, Schernthaner G, Neuhold N
II. Medizinischen Universitätsklinik Wien.
Acta Med Austriaca. 1988;15(4):117-20.
Primary aldosteronism-characterized by hypertension, hypokalemia and metabolic alkalosis--is caused by benign adenomata or bilateral adrenal hyperplasia in most cases. Aldosterone producing carcinomata of the adrenal cortex are very rare tumors. As the histological classification is difficult, the diagnosis is often drawn from tumor size, very high levels of plasma aldosterone, severe hypokalemia and malignant behaviour. The prognosis is very poor: Overall median and 5 year survival rate from diagnosis of adrenocortical carcinoma are 14 months and 24%.
原发性醛固酮增多症——以高血压、低钾血症和代谢性碱中毒为特征——在大多数情况下由良性腺瘤或双侧肾上腺增生引起。肾上腺皮质醛固酮分泌癌是非常罕见的肿瘤。由于组织学分类困难,诊断通常依据肿瘤大小、血浆醛固酮水平极高、严重低钾血症及恶性行为。预后非常差:肾上腺皮质癌诊断后的总体中位生存期和5年生存率分别为14个月和24%。