肥胖合并多囊卵巢综合征患者 Ghrelin 基因变异分析。
Variation analysis of Ghrelin gene in Chinese patients with obesity, having polycystic ovarian syndrome.
机构信息
Department of Obstetrics, The Affiliated Hospital of Qingdao University, Qingdao, China.
Department of Pediatric Cardiology, Nephrology and Rheumatology, The Affiliated Hospital of Qingdao University, Qingdao, China.
出版信息
Gynecol Endocrinol. 2020 Jul;36(7):594-598. doi: 10.1080/09513590.2020.1734786. Epub 2020 Mar 5.
Association of single-nucleotide polymorphisms (SNPs) of the ghrelin gene with polycystic ovary syndrome (PCOS)is unclear. However, their correlation with PCOS-related obesity has been observed. The objective of this study was to evaluate the effects of ghrelin gene SNPs on PCOS-related obesity in Chinese women. The full-length sequence of the ghrelin gene was determined to explore the relationship of the SNPs with PCOS-related obesity in Chinese women. The gene was sequenced, including all exons, introns and exon-intron boundaries in 230 Han Chinese women with PCOS and 162 normal women. Significant genotypic and allelic differences were observed between the obese PCOS group and obese control group at rs35681 locus ( = .013 and .017). The genotypic analysis of obese and non-obese people in the PCOS group showed that the proportion of A allele in the obese PCOS group (10.9%) was higher than that of the G allele (3.6%). This study revealed that ghrelin rs35681 might be related to the occurrence of obesity associated with PCOS, and allele A was found to increase the risk of obesity in PCOS.
ghrelin 基因单核苷酸多态性（SNPs）与多囊卵巢综合征（PCOS）的关系尚不清楚。然而，已经观察到它们与 PCOS 相关肥胖的相关性。本研究旨在评估 ghrelin 基因 SNPs 对中国女性 PCOS 相关肥胖的影响。确定 ghrelin 基因的全长序列，以探讨 SNPs 与中国女性 PCOS 相关肥胖的关系。对 230 名患有 PCOS 的汉族女性和 162 名正常女性的基因进行了测序，包括所有外显子、内含子和外显子-内含子边界。在 rs35681 位点观察到肥胖 PCOS 组和肥胖对照组之间存在显著的基因型和等位基因差异（= 0.013 和 0.017）。在 PCOS 组中对肥胖和非肥胖人群的基因分析表明，肥胖 PCOS 组中 A 等位基因（10.9%）的比例高于 G 等位基因（3.6%）。本研究表明，ghrelin rs35681 可能与 PCOS 相关肥胖的发生有关，并且发现 A 等位基因增加了 PCOS 肥胖的风险。
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