Department of Child Health, Pediatric Hematology/Oncology Unit, Sultan Qaboos University Hospital, Muscat, Oman.
Department of Pediatrics, Faculty of Medicine, University of Alexandria, Alexandria, Egypt.
Transfusion. 2020 Feb;60 Suppl 1:S22-S27. doi: 10.1111/trf.15684.
Many children with sickle cell disease (SCD) indicated for adenotonsillectomy receive pre-operative transfusion therapy, either simple or exchange transfusion, in order to reduce surgical and sickle cell disease-related complications.
This is a prospective randomized controlled clinical trial aiming to compare between preoperative simple transfusion and no transfusion in pediatric patients with sickle SCD admitted in Sultan Qaboos University Hospital, Muscat, Oman for adenotonsillectomy during the period from January 2014 through June 2018. They were randomly assigned into two arms (simple transfusion and no transfusion).
Postoperative SCD-related complications have been encountered in 6 out of 138 patients (4.3%). There was no statistically significant difference between the two studied groups as regards the development of surgical or SCD-related complications (p = 0.6 and 0.8 respectively). The length of postoperative hospital stay was comparable in the two groups. (p = 0.607). SCD-related complications occurred exclusively in cases with homozygous sickle anemia (4 out of 81 = 4.9%).
Sickle cell disease patients with a hemoglobin level above 7.5 g/dL do not need PRBCs transfusion prior to adenotonsillectomy. This approach did not increase the risk of postoperative surgical or SCD-related complications.
许多患有镰状细胞病（SCD）的儿童需要进行腺样体扁桃体切除术，为了降低手术和镰状细胞病相关并发症的风险，他们通常会接受术前输血治疗，包括单纯输血或换血。
这是一项前瞻性随机对照临床试验，旨在比较 2014 年 1 月至 2018 年 6 月期间在阿曼首都马斯喀特的苏丹卡布斯大学医院接受腺样体扁桃体切除术的镰状 SCD 儿科患者中，术前单纯输血与不输血之间的差异。他们被随机分配到两个组（单纯输血和不输血）。
138 名患者中有 6 名（4.3%）发生术后 SCD 相关并发症。两组之间在手术或 SCD 相关并发症的发展方面没有统计学差异（p=0.6 和 0.8）。两组患者的术后住院时间相似（p=0.607）。SCD 相关并发症仅发生在纯合镰状贫血患者中（81 例中有 4 例=4.9%）。
血红蛋白水平高于 7.5g/dL 的镰状细胞病患者在进行腺样体扁桃体切除术之前不需要接受 PRBCs 输血。这种方法不会增加术后手术或 SCD 相关并发症的风险。
