Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Phytother Res. 2020 Aug;34(8):1947-1955. doi: 10.1002/ptr.6659. Epub 2020 Mar 5.
Current evidence on the beneficial effects of garlic on liver enzymes is contradictory. Therefore, the aim of this systematic review and meta-analysis is to evaluate the effect of garlic supplementation on human liver enzymes, such as Alanine Transaminase (ALT/SGPT) and Aspartate Transaminase (AST/SGOT). To collect the required data, PubMed, Scopus, ISI Web of Science, and Google scholar databases were systematically searched from inception to June 2019. A meta-analysis was conducted using the random-effects model to evaluate the effects of garlic supplementation on ALT and AST levels. The Cochran's Q-test and inconsistency index were also used to evaluate heterogeneity among the studies. Among a total of 15,514 identified articles, six studies (containing 301 participants) met the inclusion criteria. Results of the meta-analysis showed that garlic supplementation significantly decreased AST level (Hedges' g = -0.36, 95% confidence interval [CI]: -0.72, -0.004, p = .047); whereas, it had no significant effect on ALT level (Hedges' g = -0.22, 95% CI: -0.64, 0.20, p = .310). Results showed that garlic supplementation reduced AST levels significantly; however, had no significant effect on ALT levels. Further studies are still needed to confirm the results.
目前关于大蒜对肝酶有益影响的证据相互矛盾。因此，本系统评价和荟萃分析的目的是评估大蒜补充剂对人类肝酶（如丙氨酸转氨酶（ALT/SGPT）和天冬氨酸转氨酶（AST/SGOT））的影响。为了收集所需的数据，从创建到 2019 年 6 月，系统地检索了 PubMed、Scopus、ISI Web of Science 和 Google Scholar 数据库。使用随机效应模型对大蒜补充剂对 ALT 和 AST 水平的影响进行了荟萃分析。还使用 Cochran's Q 检验和不一致指数来评估研究之间的异质性。在总共 15514 篇确定的文章中，有 6 项研究（包含 301 名参与者）符合纳入标准。荟萃分析结果表明，大蒜补充剂显著降低了 AST 水平（Hedges' g = -0.36，95%置信区间 [CI]：-0.72，-0.004，p =.047）；然而，对 ALT 水平没有显著影响（Hedges' g = -0.22，95% CI：-0.64，0.20，p =.310）。结果表明，大蒜补充剂可显著降低 AST 水平；然而，对 ALT 水平没有显著影响。还需要进一步的研究来证实这些结果。
