TREM2：小胶质细胞中脂质代谢的调节剂。
TREM2: Modulator of Lipid Metabolism in Microglia.
机构信息
Department of Neurology, Yale School of Medicine, New Haven, CT, USA; Department of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.
Department of Neurology, Yale School of Medicine, New Haven, CT, USA.
出版信息
Neuron. 2020 Mar 4;105(5):759-761. doi: 10.1016/j.neuron.2020.02.008.
Lipid-processing mechanisms during demyelination are poorly understood. In this issue of Neuron,Nugent et al. (2020) show by cell-specific lipidomics that Trem2 deficiency leads to cholesterol ester (CE) overload in microglia. This is mediated by misregulation of lipid metabolism genes and is rescued by modulating CE synthesis or efflux.
髓鞘脱失过程中的脂质处理机制尚未完全阐明。在本期《神经元》杂志上，Nugent 等人（2020）通过细胞特异性脂质组学研究表明，Trem2 缺失会导致小胶质细胞中的胆固醇酯（CE）过载。这种现象是由脂质代谢基因失调介导的，通过调节 CE 的合成或外排可以得到挽救。
Zotero 插件