Kawashima H, Sakamoto W, Nishijima T
Department of Urology, Toyonaka Municipal Hospital.
Hinyokika Kiyo. 1988 Sep;34(9):1683-5.
We evaluated the concentration of minocycline in human prostatic tissue. Twenty-six patients undergoing transurethral resection of prostate, two patients undergoing open prostatectomy for benign prostatic hyperplasia and two patients undergoing radical cystoprostatectomy for bladder cancer were studied. Prostatic tissue and blood were sampled at 1, 2 or 3 hours after the intravenous administration of 200 mg of minocycline. The concentration of minocycline was 2.95 +/- 1.39 micrograms/ml (mean +/- SD) in serum and 1.97 +/- 0.79 cg/g (mean +/- SD) in the prostatic tissue. The ratio of the prostatic concentration/serum concentration was 0.76 +/- 0.33 (mean +/- SD).
我们评估了米诺环素在人前列腺组织中的浓度。研究了26例接受经尿道前列腺切除术的患者、2例因良性前列腺增生接受开放性前列腺切除术的患者以及2例因膀胱癌接受根治性膀胱前列腺切除术的患者。在静脉注射200毫克米诺环素后1、2或3小时采集前列腺组织和血液样本。米诺环素在血清中的浓度为2.95±1.39微克/毫升（均值±标准差），在前列腺组织中的浓度为1.97±0.79微克/克（均值±标准差）。前列腺浓度与血清浓度之比为0.76±0.33（均值±标准差）。
