The role of prolactin in the pathogenesis of autoimmune disease.

Prolactin has emerged in recent years as a major regulator of both the maturation and the function of lymphocytes. Prolactin abnormalities, which include elevated serum levels, decreased bioactivity, abnormal circadian rhythm, and exaggerated secretion after stimulation by TRH, are associated with various autoimmune conditions in humans. Some animal experiments and observations in humans indicate that proiactin has an important role in the pathogenesis of autoimmune disease. There are several mechanisms through which prolactin could promote the development of autoimmunity. It is concluded that prolactin abnormalities alone are not likely to cause autoimmunity, but rather additional regulatory defects are perhaps also required for disease to develop.