Department of Neonatology, Assuta Medical Center, Ashdod, Israel.
Be'er Sheva School of Medicine, Ben Gurion University of the Negev, Beersheba, Israel.
J Matern Fetal Neonatal Med. 2022 Mar;35(5):958-963. doi: 10.1080/14767058.2020.1736028. Epub 2020 Mar 6.
To assess the burden of hemodynamically significant patent ductus arteriosus (hs-PDA) in preterm infants exposed to aspirin .
We retrospectively reviewed the medical records of 21 preterm infants <34 weeks whose mothers were treated with aspirin during gestation, and were screened for patent ductus arteriosus due to severe respiratory distress syndrome and the need for positive pressure ventilation. These infants were compared to 42 preterm infants born without exposure to aspirin .
We found significantly lower frequency of hs-PDA and higher rate of successful pharmacological PDA closure after single course of ibuprofen treatment along with significantly lower cumulative doses of ibuprofen in the study group. Furthermore, PDA closure was achieved significantly earlier in the study group (day 4 versus 11, = .02).
Aspirin treatment during pregnancy seemed to reduce the incidence of hs-PDA in preterm infant and to increase infant responsiveness to postnatal medical treatment of PDA.
评估在母亲孕期接受阿司匹林治疗的早产儿中出现血流动力学意义重大的动脉导管未闭（hs-PDA）的负担。
我们回顾性地分析了 21 名胎龄＜34 周且因严重呼吸窘迫综合征和需要正压通气而接受阿司匹林治疗的早产儿的病历，对其进行了动脉导管未闭的筛查。这些早产儿与 42 名未暴露于阿司匹林的早产儿进行了比较。
我们发现研究组 hs-PDA 的发生率显著降低，单次布洛芬治疗后成功关闭动脉导管未闭的比例更高，且布洛芬的累积剂量也明显较低。此外，研究组的动脉导管未闭关闭时间更早（第 4 天与第 11 天，= 0.02）。
孕期使用阿司匹林治疗似乎可以降低早产儿 hs-PDA 的发生率，并增加婴儿对出生后动脉导管未闭药物治疗的反应性。
