Evangelou Zoi, Froudarakis Marios, Ntolios Paschalis, Papoudou-Bai Alexandra, Anevlavis Stavros, Gkrepi Konstantina, Batistatou Anna, Karpathiou Georgia
Department of Pathology, University Hospital of Ioannina, Greece.
Department of Pulmonary Medicine, Democritus University of Thrace, Greece.
Pathol Res Pract. 2020 Aug;216(8):152905. doi: 10.1016/j.prp.2020.152905. Epub 2020 Feb 28.
Solitary papillomas of the lung are rare. One of their subtypes is glandular papilloma with only a very few cases described in the literature. We describe a case of pulmonary glandular papilloma with emphasis in its differential diagnosis and its molecular analysis.
A 64-years old former smoker was incidentally found to have an endobronchial tumor of the right main bronchus. Microscopic and immunohistochemical findings revealed a glandular papilloma. EGFR, KRAS and BRAF V600E mutation analysis, as well as HPV detection analysis revealed no mutation or HPV infection. Detailed differential diagnosis and literature review are presented.
Glandular papillomas of the lung are usually central, affecting older patients than squamous or mixed squamous cell and glandular papillomas. In previously reported cases, one glandular papilloma with KRAS mutation and another one with BRAF mutation have been reported. The present case harbored no mutation or HPV infection.
肺孤立性乳头状瘤较为罕见。其亚型之一为腺性乳头状瘤，文献中仅有极少数病例报道。我们描述一例肺腺性乳头状瘤病例，重点在于其鉴别诊断及分子分析。
一名64岁的既往吸烟者偶然发现右主支气管内有一肿瘤。显微镜及免疫组化检查结果显示为腺性乳头状瘤。表皮生长因子受体（EGFR）、 Kirsten大鼠肉瘤病毒癌基因（KRAS）及B-Raf原癌基因丝氨酸/苏氨酸激酶（BRAF）V600E突变分析以及人乳头瘤病毒（HPV）检测分析均未发现突变或HPV感染。本文还进行了详细的鉴别诊断及文献综述。
肺腺性乳头状瘤通常位于中央，与鳞状或混合性鳞状细胞及腺性乳头状瘤相比，发病年龄更大。在既往报道的病例中，有一例腺性乳头状瘤存在KRAS突变，另一例存在BRAF突变。本病例未发现突变或HPV感染。
