• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

雌性大鼠的免疫介导发热反应：中枢下丘脑介质的作用。

Immune-mediated febrile response in female rats: Role of central hypothalamic mediators.

机构信息

Department of Pharmacology, Federal University of Paraná, Curitiba, PR, Brazil.

Linköping University, Linköping, Sweden.

出版信息

Sci Rep. 2020 Mar 5;10(1):4073. doi: 10.1038/s41598-020-61210-z.

DOI:10.1038/s41598-020-61210-z
PMID:32139801
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7058003/
Abstract

Lipopolysaccharide (LPS) induces fever through cytokines like receptor-activator of nuclear factor κB ligand (RANKL), triggering mediators like prostaglandins (PG), endothelin-1 (ET-1), corticotrophin-releasing factor (CRF), substance P (SP) and endogenous opioids. LPS-induced fever is reduced in females compared with males except in ovariectomized (OVX) females which show increased fever mediated by PG. The present study aimed to identify the mediators involved in fever in intact and OVX female rats. Fever was induced with LPS (50 μg/kg) intraperitoneally or CRF (2.5 μg), ET-1 (1 pg), morphine (10 μg) and SP (500 ng) intracerebroventricularly in sham-operated and OVX rats. The role of RANKL was evaluated with osteoprotegerin (OPG, 1 μg, intracerebroventricularly). Expression of RANK, CRF, ET, μ-opioid (MOR) and NK receptors was evaluated by confocal microscopy. Besides LPS, only morphine induced fever in OVX rats while all mediators induced fever in sham-operated animals. OPG abolished LPS-induced fever in OVX but not sham-operated animals. Overall, fever involves similar central mediators in cycling females and males but only morphine induced fever in OVX females. Importantly, RANK/RANKL participates in LPS-induced fever in OVX females, as in males but not in cycling females.

摘要

脂多糖 (LPS) 通过细胞因子如核因子 κB 配体受体激活剂 (RANKL) 诱导发热，触发前列腺素 (PG)、内皮素-1 (ET-1)、促肾上腺皮质释放因子 (CRF)、P 物质 (SP) 和内源性阿片类物质等介质。与男性相比，雌性 LPS 诱导的发热减少，但去卵巢 (OVX) 雌性除外，其发热由 PG 介导增加。本研究旨在确定完整和 OVX 雌性大鼠发热中涉及的介质。通过 LPS（50 μg/kg）腹膜内或 CRF（2.5μg）、ET-1（1pg）、吗啡（10μg）和 SP（500ng）脑室内注射诱导 sham 操作和 OVX 大鼠发热。通过核因子 κB 配体受体激活剂 (RANKL) 评估 OPG（1μg，脑室内）的作用。通过共聚焦显微镜评估 RANK、CRF、ET、μ-阿片 (MOR) 和 NK 受体的表达。除 LPS 外，只有吗啡在 OVX 大鼠中引起发热，而所有介质在 sham 操作的动物中均引起发热。OPG 消除了 LPS 在 OVX 但不在 sham 操作的动物中引起的发热。总的来说，发热涉及循环雌性和雄性中相似的中枢介质，但只有吗啡在 OVX 雌性中引起发热。重要的是，RANK/RANKL 参与 LPS 诱导的 OVX 雌性发热，与雄性相似，但不参与循环雌性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2121/7058003/84f0eea3af22/41598_2020_61210_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2121/7058003/8cbd7d359d14/41598_2020_61210_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2121/7058003/f2a88a3947b8/41598_2020_61210_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2121/7058003/a5c62189c3db/41598_2020_61210_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2121/7058003/56d6772a010a/41598_2020_61210_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2121/7058003/18418d5e51b9/41598_2020_61210_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2121/7058003/7cd9f89fd70c/41598_2020_61210_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2121/7058003/5b7295067a85/41598_2020_61210_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2121/7058003/84f0eea3af22/41598_2020_61210_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2121/7058003/8cbd7d359d14/41598_2020_61210_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2121/7058003/f2a88a3947b8/41598_2020_61210_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2121/7058003/a5c62189c3db/41598_2020_61210_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2121/7058003/56d6772a010a/41598_2020_61210_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2121/7058003/18418d5e51b9/41598_2020_61210_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2121/7058003/7cd9f89fd70c/41598_2020_61210_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2121/7058003/5b7295067a85/41598_2020_61210_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2121/7058003/84f0eea3af22/41598_2020_61210_Fig8_HTML.jpg

相似文献

1
Immune-mediated febrile response in female rats: Role of central hypothalamic mediators.雌性大鼠的免疫介导发热反应：中枢下丘脑介质的作用。
Sci Rep. 2020 Mar 5;10(1):4073. doi: 10.1038/s41598-020-61210-z.
2
Female Sex Hormones Influence the Febrile Response Induced by Lipopolysaccharide, Cytokines and Prostaglandins but not by Interleukin-1β in Rats.雌性激素影响脂多糖、细胞因子和前列腺素诱导的大鼠发热反应，但不影响白细胞介素-1β诱导的发热反应。
J Neuroendocrinol. 2016 Oct;28(10). doi: 10.1111/jne.12414.
3
Fever Induced by Zymosan A and Polyinosinic-Polycytidylic Acid in Female Rats: Influence of Sex Hormones and the Participation of Endothelin-1.酵母聚糖 A 和聚肌苷酸聚胞苷酸在雌性大鼠中引起的发热：性激素的影响和内皮素-1 的参与。
Inflammation. 2021 Feb;44(1):321-333. doi: 10.1007/s10753-020-01335-5. Epub 2020 Sep 1.
4
Endogenous opioids: role in prostaglandin-dependent and -independent fever.内源性阿片类物质：在前列腺素依赖性和非依赖性发热中的作用
Am J Physiol Regul Integr Comp Physiol. 2008 Feb;294(2):R411-20. doi: 10.1152/ajpregu.00465.2007. Epub 2007 Nov 21.
5
Evidence of substance P autocrine circuitry that involves TNF-α, IL-6, and PGE2 in endogenous pyrogen-induced fever.内源性致热原诱导发热过程中涉及肿瘤坏死因子-α、白细胞介素-6和前列腺素E2的P物质自分泌回路的证据。
J Neuroimmunol. 2016 Apr 15;293:1-7. doi: 10.1016/j.jneuroim.2016.01.016. Epub 2016 Jan 27.
6
Genistein and Silicon Synergistically Protects Against Ovariectomy-Induced Bone Loss Through Upregulating OPG/RANKL Ratio.染料木黄酮和硅协同通过上调 OPG/RANKL 比值保护去卵巢诱导的骨丢失。
Biol Trace Elem Res. 2019 Apr;188(2):441-450. doi: 10.1007/s12011-018-1433-8. Epub 2018 Jul 16.
7
CCL3/MIP-1 alpha is not involved in the LPS-induced fever and its pyrogenic activity depends on CRF.CCL3/巨噬细胞炎性蛋白-1α不参与脂多糖诱导的发热，其致热活性依赖于促肾上腺皮质激素释放因子。
Brain Res. 2009 May 7;1269:54-60. doi: 10.1016/j.brainres.2009.03.003. Epub 2009 Mar 12.
8
Changes in central and peripheral inflammatory responses to lipopolysaccharide in ovariectomized female rats.去卵巢雌性大鼠对脂多糖的中枢和外周炎症反应的变化。
Cytokine. 2014 Jan;65(1):65-73. doi: 10.1016/j.cyto.2013.10.004. Epub 2013 Oct 31.
9
Effects of ovariectomy on the inflammatory responses of female rats to the central injection of lipopolysaccharide.卵巢切除术对雌性大鼠中枢注射脂多糖后炎症反应的影响。
J Neuroimmunol. 2014 Dec 15;277(1-2):50-6. doi: 10.1016/j.jneuroim.2014.09.017. Epub 2014 Oct 2.
10
ET receptors are involved in the febrile response induced by high dose of bacterial endotoxin.内皮素受体参与大剂量细菌内毒素引起的发热反应。
J Therm Biol. 2021 Jan;95:102804. doi: 10.1016/j.jtherbio.2020.102804. Epub 2020 Dec 4.

引用本文的文献

1
Optimum Fermentation Conditions for Bovine Lactoferricin-Lactoferrampin-Encoding and Regulation of Intestinal Inflammation.牛乳铁蛋白肽-乳铁杀菌肽编码的最佳发酵条件及肠道炎症的调节
Foods. 2023 Nov 9;12(22):4068. doi: 10.3390/foods12224068.
2
Microbial and Host Metabolites at the Backstage of Fever: Current Knowledge about the Co-Ordinate Action of Receptors and Molecules Underlying Pathophysiology and Clinical Implications.发热背后的微生物与宿主代谢产物：关于病理生理学及临床意义背后的受体与分子协同作用的当前认知
Metabolites. 2023 Mar 22;13(3):461. doi: 10.3390/metabo13030461.
3
Role of central endothelin-1 in hyperalgesia, anhedonia, and hypolocomotion induced by endotoxin in male rats.

本文引用的文献

1
Chronic exposure to low doses of estradiol-17ß increases blood pressure in young female rats: A possible role for central Endothelin-1.慢性低剂量雌二醇-17β暴露会增加年轻雌性大鼠的血压：可能与中枢内皮素-1 有关。
Sci Rep. 2017 Mar 10;7(1):139. doi: 10.1038/s41598-017-00213-9.
2
Female Sex Hormones Influence the Febrile Response Induced by Lipopolysaccharide, Cytokines and Prostaglandins but not by Interleukin-1β in Rats.雌性激素影响脂多糖、细胞因子和前列腺素诱导的大鼠发热反应，但不影响白细胞介素-1β诱导的发热反应。
J Neuroendocrinol. 2016 Oct;28(10). doi: 10.1111/jne.12414.
3
Central mediators involved in the febrile response: effects of antipyretic drugs.
中枢内皮素-1 在雄性大鼠内毒素诱导的痛觉过敏、快感缺失和运动减少中的作用。
Exp Brain Res. 2021 Jan;239(1):267-277. doi: 10.1007/s00221-020-05929-1. Epub 2020 Nov 4.
4
The Emerging Role of MicroRNAs and Other Non-Coding RNAs in Cancer Cachexia.微小RNA及其他非编码RNA在癌症恶病质中的新作用
Cancers (Basel). 2020 Apr 19;12(4):1004. doi: 10.3390/cancers12041004.
发热反应中的中枢介质：退热药的作用
Temperature (Austin). 2015 Oct 13;2(4):506-21. doi: 10.1080/23328940.2015.1102802. eCollection 2015 Oct-Dec.
4
Evidence of substance P autocrine circuitry that involves TNF-α, IL-6, and PGE2 in endogenous pyrogen-induced fever.内源性致热原诱导发热过程中涉及肿瘤坏死因子-α、白细胞介素-6和前列腺素E2的P物质自分泌回路的证据。
J Neuroimmunol. 2016 Apr 15;293:1-7. doi: 10.1016/j.jneuroim.2016.01.016. Epub 2016 Jan 27.
5
Ovarian hormones modulate endothelin A and B receptor expression.卵巢激素调节内皮素A和B受体的表达。
Life Sci. 2016 Aug 15;159:148-152. doi: 10.1016/j.lfs.2016.01.010. Epub 2016 Jan 8.
6
Effects of ovariectomy on the inflammatory responses of female rats to the central injection of lipopolysaccharide.卵巢切除术对雌性大鼠中枢注射脂多糖后炎症反应的影响。
J Neuroimmunol. 2014 Dec 15;277(1-2):50-6. doi: 10.1016/j.jneuroim.2014.09.017. Epub 2014 Oct 2.
7
Changes in central and peripheral inflammatory responses to lipopolysaccharide in ovariectomized female rats.去卵巢雌性大鼠对脂多糖的中枢和外周炎症反应的变化。
Cytokine. 2014 Jan;65(1):65-73. doi: 10.1016/j.cyto.2013.10.004. Epub 2013 Oct 31.
8
Different actions of endothelin-1 on chemokine production in rat cultured astrocytes: reduction of CX3CL1/fractalkine and an increase in CCL2/MCP-1 and CXCL1/CINC-1.内皮素-1 对大鼠培养星形胶质细胞趋化因子产生的不同作用：CX3CL1/fractalkine 的减少和 CCL2/MCP-1 以及 CXCL1/CINC-1 的增加。
J Neuroinflammation. 2013 Apr 30;10:51. doi: 10.1186/1742-2094-10-51.
9
RANKL/RANK-beyond bones.RANKL/RANK—超越骨骼。
J Mol Med (Berl). 2011 Jul;89(7):647-56. doi: 10.1007/s00109-011-0749-z. Epub 2011 Mar 29.
10
The antipyretic effect of dipyrone is unrelated to inhibition of PGE(2) synthesis in the hypothalamus.双氯芬酸的解热作用与抑制下丘脑 PGE(2)合成无关。
Br J Pharmacol. 2011 Mar;162(6):1401-9. doi: 10.1111/j.1476-5381.2010.01150.x.