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Portal Hypertension and Cirrhosis: From Evolving Concepts to Better Therapies.

作者信息

Bosch Jaume

机构信息

Department of BioMedical Research Inselspital University Hospital Bern Bern Switzerland.

Institut d'Investigacions Biomèdiques August Pi i Sunyer Barcelona Spain.

出版信息

Clin Liver Dis (Hoboken). 2020 Mar 2;15(Suppl 1):S8-S12. doi: 10.1002/cld.844. eCollection 2020 Feb.

DOI:10.1002/cld.844
PMID:32140209
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7050946/
Abstract
摘要

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本文引用的文献

1
β blockers to prevent decompensation of cirrhosis in patients with clinically significant portal hypertension (PREDESCI): a randomised, double-blind, placebo-controlled, multicentre trial.β 受体阻滞剂预防有临床显著门静脉高压症的肝硬化失代偿（PREDESCI）：一项随机、双盲、安慰剂对照、多中心试验。
Lancet. 2019 Apr 20;393(10181):1597-1608. doi: 10.1016/S0140-6736(18)31875-0. Epub 2019 Mar 22.
2
Simvastatin Prevents Progression of Acute on Chronic Liver Failure in Rats With Cirrhosis and Portal Hypertension.辛伐他汀可预防肝硬化和门静脉高压大鼠的慢加急性肝衰竭进展。
Gastroenterology. 2018 Nov;155(5):1564-1577. doi: 10.1053/j.gastro.2018.07.022. Epub 2018 Jul 25.
3
Preemptive-TIPS Improves Outcome in High-Risk Variceal Bleeding: An Observational Study.预防性 TIPS 可改善高危静脉曲张出血患者的预后：一项观察性研究。
Hepatology. 2019 Jan;69(1):282-293. doi: 10.1002/hep.30182. Epub 2018 Dec 10.
4
Portal hypertensive bleeding in cirrhosis: Risk stratification, diagnosis, and management: 2016 practice guidance by the American Association for the study of liver diseases.肝硬化门静脉高压出血：风险分层、诊断及管理：美国肝病研究协会2016年实践指南
Hepatology. 2017 Jan;65(1):310-335. doi: 10.1002/hep.28906. Epub 2016 Dec 1.
5
Transjugular Intrahepatic Portosystemic Shunts With Covered Stents Increase Transplant-Free Survival of Patients With Cirrhosis and Recurrent Ascites.经颈静脉肝内门体分流术联合覆膜支架增加肝硬化并复发性腹水患者的无移植生存率。
Gastroenterology. 2017 Jan;152(1):157-163. doi: 10.1053/j.gastro.2016.09.016. Epub 2016 Sep 20.
6
Simvastatin Attenuates Liver Injury in Rodents with Biliary Cirrhosis Submitted to Hemorrhage/Resuscitation.辛伐他汀减轻胆道性肝硬化并经历出血/复苏的啮齿动物的肝损伤。
Shock. 2017 Mar;47(3):370-377. doi: 10.1097/SHK.0000000000000734.
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Beta-blockers in 2016: Still the safest and most useful drugs for portal hypertension?2016年的β受体阻滞剂：仍是治疗门静脉高压最安全、最有效的药物吗？
Hepatology. 2016 Jun;63(6):1771-3. doi: 10.1002/hep.28502. Epub 2016 Mar 22.
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Addition of Simvastatin to Standard Therapy for the Prevention of Variceal Rebleeding Does Not Reduce Rebleeding but Increases Survival in Patients With Cirrhosis.辛伐他汀联合标准疗法预防静脉曲张再出血不能降低再出血率，但可提高肝硬化患者生存率。
Gastroenterology. 2016 May;150(5):1160-1170.e3. doi: 10.1053/j.gastro.2016.01.004. Epub 2016 Jan 14.
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Esophageal balloon tamponade versus esophageal stent in controlling acute refractory variceal bleeding: A multicenter randomized, controlled trial.食管球囊填塞与食管支架治疗急性难治性静脉曲张出血的多中心随机对照研究。
Hepatology. 2016 Jun;63(6):1957-67. doi: 10.1002/hep.28360. Epub 2016 Jan 14.
10
Evolution in the understanding of the pathophysiological basis of portal hypertension: How changes in paradigm are leading to successful new treatments.门静脉高压病理生理基础认识的演变：范式转变如何引领成功的新治疗方法。
J Hepatol. 2015 Apr;62(1 Suppl):S121-30. doi: 10.1016/j.jhep.2015.01.003.