Giolito María V, Camacho Cristian M, Martinez-Amezaga Maitena, Traficante Carla I, Giordano Rocío A, Cornier Patricia G, Mata Ernesto G, Delpiccolo Carina Ml, Boggián Dora B, Giúdice Antonela Del, Mainetti Leandro E, Scharovsky Olga G, Rozados Viviana R, Rico María J
Instituto de Genética Experimental, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Santa Fe 3100, Rosario 2000, Argentina.
Instituto de Química Rosario (CONICET-UNR), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, Rosario 2000, Argentina.
Future Sci OA. 2020 Jan 23;6(3):FSOA442. doi: 10.2144/fsoa-2019-0057.
According to the need for the development of new anticancer agents, we have synthetized novel bioactive compounds and aimed to determine their antitumor action.
MATERIALS & METHODS: We describe studies evaluating the effect of 35 novel chemical compounds on two triple negative murine mammary adenocarcinoma tumors.
RESULTS & CONCLUSION: Three compounds were selected because of their high antitumor activity and their low toxicity to normal cells. Their effect on tumor cells apoptosis, clonogenicity and migratory capacity, were determined. We found that the selected compounds showed inhibition of viability and clonogenic capacity, and promotion of apoptosis. They also decreased the migratory capacity of tumor cells. The results obtained suggest the likelihood of their future use as antitumor and/or antimetastatic agents.
根据新型抗癌药物开发的需求，我们合成了新型生物活性化合物，并旨在确定其抗肿瘤作用。
我们描述了评估35种新型化合物对两种三阴性小鼠乳腺腺癌肿瘤的影响的研究。
由于三种化合物具有高抗肿瘤活性且对正常细胞毒性低，因此被选中。确定了它们对肿瘤细胞凋亡、克隆形成能力和迁移能力的影响。我们发现所选化合物显示出对活力和克隆形成能力的抑制，并促进了细胞凋亡。它们还降低了肿瘤细胞的迁移能力。所获得的结果表明它们未来有可能用作抗肿瘤和/或抗转移药物。
