Department of Cancer Experiences Research, Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, VIC, 3000, Australia.
Australian Cancer Survivorship Centre, a Richard Pratt Legacy, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Qual Life Res. 2020 Aug;29(8):2021-2027. doi: 10.1007/s11136-020-02464-y. Epub 2020 Mar 5.
There is a lack of population-based data describing patient reported outcomes (PROs) in melanoma survivors which could guide the development of interventions and resources. This study assessed overall quality of life (QoL), self-reported symptoms and unmet information needs in melanoma survivors 1, 3 or 5 years post-diagnosis.
A cross-sectional postal survey was conducted in Victoria, Australia, with eligible melanoma survivors identified from a population-based cancer registry. Patient-reported outcome measures included the EuroQoL 5-Dimension 5-Level (EQ-5D-5L), and self-reported symptoms, difficulties and information needs. Associations between demographic, disease and care-related factors and QoL were also assessed.
A total of 476 melanoma survivors participated in the study (response rate 46.5%). Anxiety and depressive symptoms were more prevalent in survivors compared to the general population (30.7% vs 21.6%; p < 0.01). Fear of cancer recurrence (48.3%) and fear of cancer spreading (37.8%) were the most commonly reported symptom items, and approximately one in five melanoma survivors had unmet information needs related to psychological aspects of living with melanoma. Recurrent melanoma, living in a nursing home, chronic comorbidities, and melanoma diagnosed at > 2 mm thickness were associated with lower QoL.
A large proportion of melanoma survivors reported ongoing quality of life deficits, fear of cancer recurrence, as well as unmet information needs up to 5 years after diagnosis. Patients may benefit from tailored informational resources and interventions that address the psychological aspects of living with and beyond melanoma.
目前缺乏描述黑素瘤幸存者患者报告结局（PROs）的基于人群的数据，这些数据可以为干预措施和资源的开发提供指导。本研究评估了诊断后 1、3 或 5 年的黑素瘤幸存者的总体生活质量（QoL）、自我报告的症状和未满足的信息需求。
在澳大利亚维多利亚州进行了一项横断面邮寄调查，从基于人群的癌症登记处确定了合格的黑素瘤幸存者。患者报告的结局测量包括欧洲五维健康量表 5 维 5 级量表（EQ-5D-5L），以及自我报告的症状、困难和信息需求。还评估了人口统计学、疾病和护理相关因素与 QoL 之间的关联。
共有 476 名黑素瘤幸存者参与了这项研究（应答率为 46.5%）。与一般人群相比，幸存者的焦虑和抑郁症状更为普遍（30.7%比 21.6%；p<0.01）。对癌症复发的恐惧（48.3%）和对癌症扩散的恐惧（37.8%）是最常报告的症状项目，大约五分之一的黑素瘤幸存者有未满足的与癌症相关的心理信息需求。复发性黑素瘤、居住在疗养院、慢性合并症以及诊断厚度>2mm 的黑素瘤与较低的 QoL 相关。
很大一部分黑素瘤幸存者报告在诊断后 5 年内仍存在生活质量下降、对癌症复发的恐惧以及未满足的信息需求。患者可能受益于针对与癌症相关的心理方面的个性化信息资源和干预措施。
