Centro Nacional de Investigaciones Cardiovasculares (CNIC), Calle de Melchor Fernández Almagro, 3, 28029, Madrid, Spain.
Servicio de Cardiología, Hospital Universitario de La Princesa, Madrid, Spain.
J Cardiovasc Transl Res. 2021 Feb;14(1):150-160. doi: 10.1007/s12265-020-09974-7. Epub 2020 Mar 5.
Colchicine demonstrated clinical benefits in the treatment of stable coronary artery disease. Our aim was to evaluate the effects of colchicine on atherosclerotic plaque stabilization. Atherosclerosis was induced in the abdominal aorta of 20 rabbits with high-cholesterol diet and balloon endothelial denudation. Rabbits were randomized to receive either colchicine or placebo. All animals underwent MRI, F-FDG PET/CT, optical coherence tomography (OCT), and histology. Similar progression of atherosclerotic burden was observed in the two groups as relative increase of normalized wall index (NWI). Maximum F-FDG standardized uptake value (meanSUVmax) decreased after colchicine treatment, while it increased in the placebo group with a trend toward significance. Animals with higher levels of cholesterol showed significant differences in favor to colchicine group, both as NWI at the end of the protocol and as relative increase in meanSUVmax. Colchicine may stabilize atherosclerotic plaque by reducing inflammatory activity and plaque burden, without altering macrophage infiltration or plaque typology.
秋水仙碱在治疗稳定型冠状动脉疾病方面显示出临床益处。我们的目的是评估秋水仙碱对动脉粥样硬化斑块稳定化的影响。通过高胆固醇饮食和球囊内皮剥脱术在 20 只兔子的腹主动脉中诱导动脉粥样硬化。兔子被随机分为秋水仙碱组或安慰剂组。所有动物均接受 MRI、F-FDG PET/CT、光学相干断层扫描（OCT）和组织学检查。两组的动脉粥样硬化负担均呈相似的进展，即归一化壁指数（NWI）的相对增加。秋水仙碱治疗后 F-FDG 标准化摄取最大值（meanSUVmax）降低，而安慰剂组则升高，有显著意义的趋势。胆固醇水平较高的动物在 NWI 终末和 meanSUVmax 的相对增加方面均显示出有利于秋水仙碱组的显著差异。秋水仙碱通过减少炎症活性和斑块负担来稳定动脉粥样硬化斑块，而不改变巨噬细胞浸润或斑块类型。
