Deacon A C
Clinical Chemistry Department, Northwick Park Hospital, Harrow, Middlesex, UK.
Ann Clin Biochem. 1988 Jul;25 ( Pt 4):392-7. doi: 10.1177/000456328802500412.
The clinical utility of screening tests for porphyria has been assessed in 201 cases referred to Northwick Park Hospital. Routine screening in the referring laboratories was unreliable giving both false negative and positive results. Only 43% of porphyrics were correctly identified, apparently due to poor analytical sensitivity. Evidence is presented to show that the adoption of alternative semiquantitative tests for porphyrins employing spectrophotometric scanning of acidified urine or of faecal extracts will overcome many of these problems.
在转诊至诺斯威克公园医院的201例患者中，已对血卟啉病筛查试验的临床效用进行了评估。转诊实验室的常规筛查不可靠，会出现假阴性和假阳性结果。显然由于分析灵敏度较差，只有43%的血卟啉病患者被正确识别。有证据表明，采用对酸化尿液或粪便提取物进行分光光度扫描的血卟啉替代半定量检测方法，将克服其中许多问题。
