From the Gemini Eye Clinic, Zlin (Stodulka, Halasova, Slovak, Martin, Liska, Polisensky), and Ophthalmology Department, Third Faculty of Medicine, Charles University, (Stodulka), and Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague (Sramka), Prague, Czech Republic.
J Cataract Refract Surg. 2020 Mar;46(3):434-440. doi: 10.1097/j.jcrs.0000000000000074.
To evaluate the efficacy of epithelium-on photorefractive intrastromal crosslinking (PiXL), a noninvasive procedure to reduce refractive error in patients with low hyperopia.
Gemini Eye Clinic, Zlin, Czech Republic.
Prospective single-center study.
Twenty-two low hyperopic eyes were enrolled and underwent PiXL treatment according to a standardized treatment protocol. Visual acuity, subjective distance refraction, keratometry, topography, pachymetry, subjective discomfort, and endothelial cell density (ECD) were recorded during 12-month follow-up.
In 22 eyes, the median manifest refraction decreased significantly (P < .0001) from +0.75 diopters (D) (interquartile range [IQR], +0.63 to +1.06 D), median and IQR) diopters (D) preoperatively to +0.25 D (IQR, 0.0 to +0.50 D) at 12-month follow-up and remained stable. Seventy-seven percent of eyes achieved refraction within ± 0.50 D of emmetropia by 1 month postoperatively and was stable through 12-month follow-up. ECD was stable and did not show significant changes. There was low incidence of postoperative pain and dry eye.
PiXL is a promising alternative to conventional laser refractive surgeries for low hyperopia. Further studies are warranted to optimize treatment parameters for a wider range of refractive errors and to evaluate the potential to improve precision.
评估上皮下光致折射性间质交联（PiXL）的疗效，这是一种非侵入性的治疗方法，可降低低度远视患者的屈光不正。
捷克兹林双子座眼科诊所。
前瞻性单中心研究。
22 只低度远视眼按标准治疗方案接受 PiXL 治疗。在 12 个月的随访期间记录视力、主观距离屈光、角膜曲率、地形图、角膜厚度、主观不适和内皮细胞密度（ECD）。
22 只眼中，22 只眼中的中位数表现折射显著降低（P <.0001），从术前+0.75 屈光度（D）（四分位间距[IQR]，+0.63 至+1.06 D）降至术后 12 个月随访时的+0.25 D（IQR，0.0 至+0.50 D），且稳定。77%的眼在术后 1 个月内达到屈光度在± 0.50 D 以内的正视，在 12 个月的随访中保持稳定。ECD 稳定，无明显变化。术后疼痛和干眼症发生率较低。
PiXL 是治疗低度远视的一种有前途的传统激光屈光手术替代方法。需要进一步的研究来优化治疗参数，以治疗更广泛的屈光不正，并评估提高精度的潜力。
