Division of Psychiatry, University College London, London, UK.
Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK; Physiotherapy Department, South London and Maudsley National Health Services Foundation Trust, London, UK.
Maturitas. 2020 Apr;134:1-7. doi: 10.1016/j.maturitas.2020.01.007. Epub 2020 Jan 13.
Physical multimorbidity, defined as the presence of two or more chronic physical conditions, is widespread and reduces life expectancy and quality of life in older adults. Sedentary behavior (SB) is increasingly identified as a risk factor for a range of chronic physical conditions, independent of physical activity.
To investigate associations between physical multimorbidity and SB in older adults.
We used cross-sectional data from a population-based sample of 6903 adults aged ≥50 years who participated in the Irish Longitudinal Study on Ageing (TILDA) in 2009-2011. We conducted multivariable linear and logistic regression analyses to assess associations between multimorbidity and SB.
Self-reported minutes/day of SB and high SB (≥ 8 h/day).
We found that most of the 14 individual chronic physical conditions included here were associated with greater SB. Those with stroke (OR = 2.63, 95 % CI = 1.69, 4.10) and cirrhosis (OR = 2.53, 95 %CI = 1.19, 5.41) were the most likely to be classified with high SB. Time spent in SB and the prevalence of high SB increased linearly with number of chronic conditions. Multivariable regression models adjusting for sociodemographic and psychological factors, disability, social network, and physical activity showed that, compared with people with none, those with ≥4 chronic physical conditions had 1.45 times greater odds (OR = 1.45, 95 % CI = 1.09, 1.93) of high SB and higher mean minutes/day of SB (β = 21.37, 95 % CI = 5.53, 37.20).
Our results suggest that physical multimorbidity is associated with SB and highlight the need for prospective research to examine the directionality and mechanisms of these associations.
身体多病共存，定义为同时患有两种或两种以上慢性躯体疾病，在老年人中广泛存在，并降低其预期寿命和生活质量。久坐行为（SB）越来越被认为是一系列慢性躯体疾病的危险因素，独立于身体活动。
研究老年人中身体多病共存与 SB 的关系。
我们使用了 2009-2011 年参与爱尔兰老龄化纵向研究（TILDA）的≥50 岁人群的基于人群的样本的横断面数据。我们进行了多变量线性和逻辑回归分析，以评估多病共存与 SB 之间的关联。
自我报告的每天 SB 分钟数和高 SB（≥8 小时/天）。
我们发现，这里包含的 14 种慢性躯体疾病中的大多数与更多的 SB 有关。患有中风（OR=2.63，95%CI=1.69，4.10）和肝硬化（OR=2.53，95%CI=1.19，5.41）的人最有可能被归类为高 SB。SB 时间和高 SB 的患病率随慢性疾病数量呈线性增加。调整社会人口统计学和心理因素、残疾、社交网络和身体活动的多变量回归模型显示，与无慢性病者相比，患有≥4 种慢性躯体疾病者发生高 SB 的可能性高 1.45 倍（OR=1.45，95%CI=1.09，1.93），SB 时间更长（β=21.37，95%CI=5.53，37.20）。
我们的结果表明，身体多病共存与 SB 有关，并强调需要前瞻性研究来检验这些关联的方向性和机制。
