Tomás-Velázquez Alejandra, Escribano Ángela, Rodríguez-Garijo Nuria, Estenaga Pérez de Álbeniz Ángela, Reina Gabriel, España Agustín
Departamento de Dermatología, Clínica Universidad de Navarra, Pamplona, España.
Facultad de Medicina, Universidad de Navarra, Pamplona, España.
Med Clin (Barc). 2020 Jul 10;155(1):26-29. doi: 10.1016/j.medcli.2019.12.014. Epub 2020 Mar 3.
Parvovirus B19 (PVB19) infection has a high incidence and worldwide distribution. It has a broad clinical spectrum, with skin, joint and haematological manifestations being the most common. The objective of this study was to determine the epidemiology and clinical-analytical manifestations of acute PVB19 infection.
A retrospective study of patients with a positive IgM serology for PVB19 (10 years). Forty-six patients were included and their demographic, clinical and analytical characteristics were analyzed.
Primary infection was most prevalent in women (ratio 2.2:1) aged 41 (mean age). Joint involvement was the most common manifestation (65%). Skin abnormalities were observed in more than half of patients (24 cases): rash (28%), megalerythema (9%), "gloves and socks" involvement (6.5%), periflexural rash (4%) and oedema (4%). Anaemia was the main haematological alteration (35%). The symptoms were self-limiting and resolved in 1-2 weeks in most patients.
Although there is a variable clinical spectrum, polyarthralgias and generalized maculopapular rash with fever and anaemia are the typical and most frequent manifestations of primary infection by PVB19 and are usually self-limiting.
细小病毒B19（PVB19）感染发病率高，遍布全球。其临床表现多样，皮肤、关节和血液系统表现最为常见。本研究的目的是确定急性PVB19感染的流行病学及临床分析表现。
对PVB19 IgM血清学阳性患者进行回顾性研究（为期10年）。纳入46例患者，分析其人口统计学、临床和分析特征。
初次感染在41岁（平均年龄）女性中最为普遍（男女比例为2.2:1）。关节受累是最常见的表现（65%）。超过半数患者（24例）出现皮肤异常：皮疹（28%）、巨红斑（9%）、“手套和袜套”样受累（6.5%）、屈侧周围皮疹（4%）和水肿（4%）。贫血是主要的血液学改变（35%）。症状具有自限性，大多数患者在1 - 2周内缓解。
尽管临床表现多样，但多关节痛、伴有发热和贫血的全身性斑丘疹是PVB19初次感染的典型且最常见表现，通常具有自限性。
