Department of Neonatology, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, No. 11 Renmin West Road, Chancheng District, Foshan, 528000, China.
Foshan Institute of Fetal Medicine, Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, No. 11 Renmin West Road, Chancheng District, Foshan, 528000, China.
Pediatr Neonatol. 2020 Jun;61(3):306-310. doi: 10.1016/j.pedneo.2019.12.010. Epub 2020 Jan 29.
The study aimed to evaluate the association between microbes in the lower respiratory tract (LRT) and the srisk for severe bronchopulmonary dysplasia (sBPD) in premature infants.
We conducted a retrospective, single-center study of preterm infants who were admitted to the neonatal intensive care unit (NICU) of Southern Medical University Affiliated Maternal & Child Health Hospital of Foshan, China, between January 2015 and December 2017. The microbes in the LRT were screened by using tracheobronchial aspirate fluid (TAF) culture.
One hundred and fifty-five infants were included in the analysis. Among 155 infants, 41 were diagnosed with sBPD, and 114 were diagnosed without sBPD. There were significant differences between infants with and without sBPD in regard to birth weight (BW), gestational age (GA), the duration of endotracheal ventilation and supplemental oxygen. The incidence of retinopathy (ROP) and sepsis was higher in the sBPD infants than in the infants without sBPD. There was a difference in the detection rate of Gram-negative bacteria (GNB) between the two groups. Stenotrophomonas maltophilia and Klebsiella pneumoniae were mainly detected in TAF.
The LRT microbes were different between infants with and without sBPD, and GNB is more frequently detected in sBPD infants.
本研究旨在评估下呼吸道（LRT）微生物与早产儿严重支气管肺发育不良（sBPD）风险之间的关联。
我们进行了一项回顾性、单中心研究，纳入了 2015 年 1 月至 2017 年 12 月期间在中国佛山市南方医科大学附属妇幼保健院新生儿重症监护病房（NICU）住院的早产儿。通过气管支气管抽吸液（TAF）培养筛选 LRT 中的微生物。
155 名婴儿被纳入分析。在 155 名婴儿中，41 名被诊断为 sBPD，114 名被诊断为非 sBPD。sBPD 婴儿与非 sBPD 婴儿在出生体重（BW）、胎龄（GA）、气管内通气和补充氧气的持续时间方面存在显著差异。sBPD 婴儿的视网膜病变（ROP）和败血症发生率高于非 sBPD 婴儿。两组革兰氏阴性菌（GNB）的检出率存在差异。嗜麦芽窄食单胞菌和肺炎克雷伯菌主要在 TAF 中检出。
sBPD 婴儿与非 sBPD 婴儿的 LRT 微生物不同，sBPD 婴儿中更常检出 GNB。
