Siebenbrodt Kai, Strzelczyk Adam, Rosenow Felix
Epilepsiezentrum Frankfurt Rhein-Main, Klinik für Neurologie, Zentrum der Neurologie und Neurochirurgie, Universitätsklinikum Frankfurt, Goethe-Universität Frankfurt, Schleusenweg 2-16 (Haus 95), 60528, Frankfurt am Main, Deutschland.
Nervenarzt. 2020 Apr;91(4):353-361. doi: 10.1007/s00115-020-00888-y.
In an aging society, epilepsy in old age will become a more and more relevant disease. The diagnosis is often difficult because of the frequent occurrence of focal seizures in old age, which are easily overlooked. The diagnosis is often delayed, particularly in older patients who, for example also suffer from dementia. The causes of the epilepsy can be manifold in the aging brain. Another challenge for neurologists is the medicinal treatment of geriatric epilepsy, as many anticonvulsive drugs can be associated with serious side effects and interactions. The evidence for the effectiveness and tolerability of anticonvulsive drugs in old age is insufficient, so that the choice of drugs must be made on an individual basis. Status epilepticus is a neurological emergency, which occurs not only more frequently in older than in younger persons but is also associated with a higher mortality, so that immediate diagnosis and adequate treatment is necessary.
在老龄化社会中，老年癫痫将成为一种越来越重要的疾病。由于老年期局灶性癫痫发作频繁，且容易被忽视，其诊断往往困难。诊断常常延迟，尤其是在例如还患有痴呆症的老年患者中。癫痫在衰老大脑中的病因可能多种多样。对神经科医生来说，老年癫痫的药物治疗也是一项挑战，因为许多抗惊厥药物可能会带来严重的副作用和相互作用。抗惊厥药物在老年患者中的有效性和耐受性证据不足，因此必须根据个体情况选择药物。癫痫持续状态是一种神经急症，不仅在老年人中比年轻人更频繁发生，而且死亡率也更高，因此需要立即诊断并进行适当治疗。
