Solakivi T, Salo M K, Puska P, Nikkari T
Department of Biomedical Sciences, University of Tampere, Finland.
Atherosclerosis. 1988 Jul;72(1):55-61. doi: 10.1016/0021-9150(88)90062-7.
Plasma apolipoprotein B (apo B) concentrations were determined in 178 randomly selected 40-49-year-old men from Eastern and Southwestern Finland and compared with the concentrations of plasma lipids and the fatty acid composition of plasma and adipose tissue determined previously from the same populations. The plasma apo B concentrations ranged from 50 to 209 mg/dl. Although men from the two regions had similar mean concentrations of plasma triglyceride, total cholesterol and high density lipoprotein (HDL)-cholesterol, men from Eastern Finland had significantly higher mean apo B levels (139 +/- 25 mg/dl) and a lower ratio of total cholesterol to apo B (1.85 +/- 0.25) than the Southwestern men (125 +/- 33 mg/dl and 2.05 +/- 0.40, respectively). In the whole population, apo B and total cholesterol had significant negative correlations with the percentages of linoleate in the fatty acids of plasma and adipose tissue, which are known to reflect the quality of dietary fat. As the percentages of linoleate have previously been shown to be lower in the Eastern population, part of the regional difference in apo B is obviously explained by differences in the quality of dietary fat. On the other hand, men (n = 59) who had high plasma apo B (greater than 130 mg/dl) but low density lipoprotein (LDL)-cholesterol within the reference values (less than 5.17 mmol/l) showed no correlation between linoleate and apo B. This suggests that other factors than dietary fat determine the concentration of apo B in this group of men.
对来自芬兰东部和西南部的178名年龄在40至49岁之间的男性进行了随机抽样，测定其血浆载脂蛋白B（apo B）浓度，并与先前从同一人群中测定的血脂浓度以及血浆和脂肪组织的脂肪酸组成进行比较。血浆apo B浓度范围为50至209mg/dl。尽管两个地区的男性血浆甘油三酯、总胆固醇和高密度脂蛋白（HDL）胆固醇的平均浓度相似，但芬兰东部男性的apo B平均水平（139±25mg/dl）显著高于西南部男性（分别为125±33mg/dl），且总胆固醇与apo B的比值（1.85±0.25）低于西南部男性（2.05±0.40）。在整个人群中，apo B和总胆固醇与血浆和脂肪组织脂肪酸中亚油酸的百分比呈显著负相关，已知亚油酸百分比反映膳食脂肪质量。由于先前已表明东部人群中亚油酸百分比较低，apo B的部分地区差异显然可由膳食脂肪质量差异来解释。另一方面，血浆apo B水平较高（大于130mg/dl）但低密度脂蛋白（LDL）胆固醇在参考值范围内（小于5.17mmol/l）的男性（n = 59），亚油酸与apo B之间无相关性。这表明除膳食脂肪外，其他因素决定了这群男性的apo B浓度。
