Eto M, Watanabe K, Chonan N, Ishii K
Second Department of Internal Medicine, Asahikawa Medical College, Japan.
Atherosclerosis. 1988 Aug;72(2-3):123-8. doi: 10.1016/0021-9150(88)90072-x.
The purpose of this study was to elucidate the relationship between two genetic factors associated with raised blood cholesterol, i.e. familial hypercholesterolemia (FH) and apolipoprotein (apo) E4. A group of 50 unrelated heterozygous FH patients aged 33-71 years were studied together with 129 normolipidemic subjects. A significantly higher frequency of apo E4 phenotypes was found in FH patients (30.0%) than in normolipidemic subjects (15.5%). FH patients were divided into two groups with and without apo E4. Plasma total cholesterol (Chol) and triglyceride (TG) levels were significantly higher, and plasma low density lipoprotein-cholesterol (LDL-Chol) level tended to be higher in FH patients with apo E4 than in those without apo E4. In addition, the prevalence of ischemic heart disease (IHD) was significantly higher in FH patients with apo E4 (73.3%) than in those without apo E4 (31.4%). No significant difference was noted in age and in the prevalence of obesity, diabetes, hypertension and smoking between the FH groups with and without apo E4. These results suggest that apo E4 is associated with higher levels of total Chol and TG and, at least in part, contributes to the predisposition to IHD in FH.
本研究的目的是阐明与血液胆固醇升高相关的两个遗传因素之间的关系，即家族性高胆固醇血症（FH）和载脂蛋白（apo）E4。对一组50名年龄在33至71岁之间的无亲缘关系的杂合子FH患者以及129名血脂正常的受试者进行了研究。在FH患者中发现apo E4表型的频率（30.0%）显著高于血脂正常的受试者（15.5%）。FH患者被分为有apo E4和无apo E4两组。有apo E4的FH患者血浆总胆固醇（Chol）和甘油三酯（TG）水平显著更高，血浆低密度脂蛋白胆固醇（LDL-Chol）水平也倾向于更高。此外，有apo E4的FH患者缺血性心脏病（IHD）的患病率（73.3%）显著高于无apo E4的FH患者（31.4%）。有apo E4和无apo E4的FH组在年龄以及肥胖、糖尿病、高血压和吸烟的患病率方面未发现显著差异。这些结果表明，apo E4与更高的总Chol和TG水平相关，并且至少在一定程度上导致FH患者易患IHD。
