Maidment C G, Jones S P, Lea E J
Membrane Laboratory, School of Biological Sciences, University of East Anglia, Norwich, U.K.
Atherosclerosis. 1988 Nov;74(1-2):9-14. doi: 10.1016/0021-9150(88)90185-2.
Myocardial infarction (MI) is a common cause of morbidity and mortality, and platelets may contribute to its development. Platelet membrane composition can influence platelet function. In this study changes in platelet membrane fatty acids with time following MI were explored. Platelet membrane fatty acid profiles were studied in 40 patients after MI, at a mean of 8 days, and compared with a control group of 17 subjects awaiting minor surgery. They were restudied at 1 month and 3 months. Significant changes were found within the patient group in 18:1, which fell with time (19.99% +/- 1.24 to 18.73% +/- 1.16 at 3 months, P less than 0.001), 22:3 + 24:1, which also fell (1.97% +/- 0.48 to 1.46% +/- 0.49, P less than 0.001), and in 18:2, which increased (3.92% +/- 0.77 to 5.04% +/- 1.15 P less than 0.001). Comparison with controls showed no significant differences at baseline, a small increase in 22:4 at 1 month and 3 months in MI group and a decrease in 22:3 + 24:1 in MI group at 3 months. No changes were noted in 20:4, 20:5 or in the polyunsaturated/saturated fatty acid ratio. The explanation for these findings is not known. The possible influence of diet and other factors is discussed.
心肌梗死（MI）是发病和死亡的常见原因，血小板可能在其发展过程中起作用。血小板膜成分可影响血小板功能。本研究探讨了心肌梗死后血小板膜脂肪酸随时间的变化。对40例心肌梗死后平均8天的患者的血小板膜脂肪酸谱进行了研究，并与17例等待小手术的对照组受试者进行了比较。在1个月和3个月时对他们进行了再次研究。患者组中18:1随时间下降（3个月时从19.99%±1.24降至18.73%±1.16，P＜0.001），22:3 + 24:1也下降（从1.97%±0.48降至1.46%±0.49，P＜0.001），18:2增加（从3.92%±0.77增至5.04%±1.15，P＜0.001），差异有统计学意义。与对照组比较，基线时无显著差异，心肌梗死组在1个月和3个月时22:4略有增加，3个月时22:3 + 24:1减少。20:4、20:5或多不饱和/饱和脂肪酸比值无变化。这些发现的原因尚不清楚。讨论了饮食和其他因素的可能影响。
