Departamento de Físicoquímica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, CONICET-INFIQC Haya, de la Torre s/n, Córdoba, X5000 HUA, Argentina.
Federal University of Piaui, Pharmacy Course, Campus University Professor Petrônio Portella Ininga Neighborhood, Teresina, Piaui, 64049-901, Brazil.
ChemMedChem. 2020 May 19;15(10):851-861. doi: 10.1002/cmdc.202000048. Epub 2020 Apr 2.
Imidazoline derivatives with different exocyclic substituents were simply prepared from common starting materials. The procedures were carried out in an eco-friendly manner. The antioxidant activity of these derivatives was explored by different experimental assays, such as ABTS and DPPH scavenging assay, as well as reducing power assay. The structural differences are discussed in terms of the results. Sulfur analogs showed higher antioxidant activity than their oxygenated counterparts. The same tendency was observed in microbiological studies, in which the same imidazoline compounds were assayed for light-mediated activity against of Staphylococcus aureus and Escherichia coli strains. A light-enhanced activity was observed for almost all the sulfated imidazolines after exposure to UV-A (400-320 nm) light.
从常见的起始原料简单制备了具有不同外环取代基的咪唑啉衍生物。这些程序是以环保的方式进行的。通过不同的实验测定，如 ABTS 和 DPPH 清除测定以及还原力测定，研究了这些衍生物的抗氧化活性。根据结果讨论了结构差异。硫类似物的抗氧化活性高于其含氧类似物。在微生物研究中也观察到了相同的趋势，其中对金黄色葡萄球菌和大肠杆菌菌株的光介导活性测试了相同的咪唑啉化合物。在暴露于 UV-A（400-320nm）光后，几乎所有的硫酸化咪唑啉都观察到了光增强的活性。
