Warter A, Audouin J, Sekou H
Laboratoire d'Anatomie Pathologique, Faculté des Sciences de la Santé, Université de Niamey, Niger.
Ann Pathol. 1988;8(4-5):305-10.
Ainhum or dactylolysis spontanea is characterized by the occurrence of a circular constriction located at the root of the 5th toe, rarely of a finger. It deepens, the toe becomes disabled and finally amputation occurs, spontaneously or by surgery. It is a tropical disease of the adult, the origin of which remains obscure. It seems frequent in Niger. 7 cases have been histologically studied. Classical features have been found, including hyperkeratosis, chronic dermatitis, osteoporosis with cortical bone resorption. This study has also revealed in all cases complete ligamental destruction. Moreover, vegetal foreign body granulomas have been found in 4 cases, lying deep in the dermis and in one case in a synovial membrane. Ainhum is compared with pseudo-ainhum seen in genodermatosis, in yaws and in congenital strictures. Among the usually considered etiopathogenetic hypotheses, our findings are in favor of a mechanical and inflammatory origin.
自发性断趾症或阿洪病的特征是在小趾根部出现环形缩窄，手指很少出现。缩窄逐渐加深，趾头功能丧失，最终趾头会自行脱落或通过手术切除。这是一种成年人的热带疾病，其病因尚不清楚。该病在尼日尔似乎很常见。对7例患者进行了组织学研究。发现了典型特征，包括角化过度、慢性皮炎、伴有皮质骨吸收的骨质疏松症。该研究还发现所有病例均存在韧带完全破坏。此外，在4例患者中发现了植物性异物肉芽肿，位于真皮深层，1例位于滑膜。将阿洪病与遗传性皮肤病、雅司病和先天性狭窄中出现的假性阿洪病进行了比较。在通常考虑的病因发病机制假说中，我们的研究结果支持机械性和炎症性起源。
