[蛋白质的沉默调节蛋白家族：在衰老过程及细胞代谢调节中的作用。]
[The sirtuin family of proteins: the role in the aging processes and regulation of cell metabolism.].
作者信息
Bode I I, Medvedev D S, Kvetnoy I M, Polyakova V O
机构信息
Saint-Petersburg State University, 7-9 Universitetskaya emb., St. Petersburg 199034, Russian Federation, e-mail:
I.I.Mechnikov North-Western State Medical University, 47 Piskarevskij pr., St. Petersburg 195067, Russian Federation.
出版信息
Adv Gerontol. 2019;32(5):686-692.
In recent years, the key role of sirtuins in the regulation of the most important cellular processes has been established. Sirtuins are involved in histone deacetylation, regulation of fat and glucose metabolism. Violations of their synthesis and secretion can induce carcinogenesis, aging and cell death. The wide range of processes in which sirtuins are involved indicates their possible role in the pathogenesis of many diseases including metabolic syndrome, neurodegenerative diseases, inflammation associated diseases and tumor growth. All of these diseases are associated with aging. In this article, we analyze the existing data on sirtuins and their role in the pathogenesis of aging, as well as their possible verification as markers for the diagnosis of age-related diseases and as targets of geriatric therapy and prevention.
近年来，已证实沉默调节蛋白在调控最重要的细胞过程中发挥关键作用。沉默调节蛋白参与组蛋白去乙酰化、脂肪和葡萄糖代谢的调节。其合成与分泌的异常可诱导致癌作用、衰老及细胞死亡。沉默调节蛋白所涉及的广泛过程表明它们可能在包括代谢综合征、神经退行性疾病、炎症相关疾病及肿瘤生长在内的许多疾病的发病机制中发挥作用。所有这些疾病都与衰老相关。在本文中，我们分析了关于沉默调节蛋白及其在衰老发病机制中的作用的现有数据，以及它们作为诊断与年龄相关疾病的标志物以及老年治疗和预防靶点进行验证的可能性。
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