Laboratory of Immunobiology, Institute for Molecular Biology and Medicine, Université Libre de Bruxelles, Gosselies, Belgium.
J Leukoc Biol. 2013 May;93(5):669-80. doi: 10.1189/jlb.1112557. Epub 2013 Jan 16.
Lysine deacetylation by the NAD(+)-dependent family of sirtuins has been recognized as an important post-translational modification regulating a wide range of cellular processes. These lysine deacetylases have attracted much interest based on their ability to promote survival in response to stress. Sirtuins require NAD(+) for their enzymatic activity, suggesting that these enzymes may represent molecular links between cell metabolism and several human disorders, including diabetes and cancer. Inflammation represents a pathological situation with clear connections to metabolism and aging in humans, raising the possibility that sirtuins may also play an important role during a normal and/or a pathological immune response. A growing body of data has confirmed the immunomodulatory properties of sirtuins, although often with contrasting and opposing conclusions. These observations will be summarized herein and the possible strategies that may lead to the development of novel therapeutic approaches to treat inflammation briefly discussed.
赖氨酸的去乙酰化作用由 NAD(+)依赖的 sirtuins 家族调控，这被认为是调节广泛的细胞过程的一种重要的翻译后修饰。这些赖氨酸去乙酰酶由于其在应激反应中促进存活的能力而引起了广泛关注。sirtuins 需要 NAD(+)才能发挥酶活性，这表明这些酶可能代表细胞代谢与包括糖尿病和癌症在内的几种人类疾病之间的分子联系。炎症是一种与人类代谢和衰老有明显联系的病理情况，这增加了 sirtuins 在正常和/或病理性免疫反应中可能也发挥重要作用的可能性。越来越多的证据证实了 sirtuins 的免疫调节特性，尽管这些证据往往存在相互矛盾和对立的结论。本文将对这些观察结果进行总结，并简要讨论可能导致开发新型治疗炎症方法的策略。
