Population Research Unit, Faculty of Social Sciences, University of Helsinki, P.O. Box 18, FIN-00014 Helsinki, Finland; London School of Economics and Political Science, Department of Social Policy, London WC2A 2AE, United Kingdom.
Population Research Unit, Faculty of Social Sciences, University of Helsinki, P.O. Box 18, FIN-00014 Helsinki, Finland.
Drug Alcohol Depend. 2020 Apr 1;209:107942. doi: 10.1016/j.drugalcdep.2020.107942. Epub 2020 Feb 27.
Men's age at first birth may negatively or positively affect alcohol-related morbidity and mortality, although little evidence is available.
We used register data of over 22,000 brothers to analyze the associations between age at first birth and alcohol-related morbidity and mortality from the age of 35 until the age of 60 or 72. We employed conventional Cox models and inter-sibling models, which allowed adjustment for unobserved social and genetic characteristics shared by brothers.
The findings show that men's age at first birth was inversely associated with alcohol-related morbidity and mortality, independent of unobserved characteristics shared by brothers and of observed demographic confounders. Men who had their first child late at 35-45 years experienced lower alcohol-related morbidity and mortality (hazard ratio (HR) = 0.57, 95 % confidence interval (CI) = 0.43, 0.75) than men who had their first child at 25-29. Men who had their first child before age 20 had the highest morbidity and mortality among all fathers (HR = 1.36, 95 % CI = 1.09, 1.69), followed by men who had their child at 20-24 (HR = 1.12, 95 % CI = 1.00, 1.25).
The results imply that the inverse association between men's age at first birth and alcohol-related morbidity and mortality is not driven by familial characteristics.
男性首次生育年龄可能对与酒精相关的发病率和死亡率产生负面影响或正面影响，但相关证据有限。
我们利用超过 22000 名兄弟的登记数据，通过常规 Cox 模型和同胞间模型分析了首次生育年龄与 35 岁至 60 岁或 72 岁期间与酒精相关的发病率和死亡率之间的关联。同胞间模型允许对兄弟之间共同的未观察到的社会和遗传特征进行调整。
研究结果表明，男性首次生育年龄与与酒精相关的发病率和死亡率呈负相关，这与兄弟间共同的未观察到的特征以及观察到的人口统计学混杂因素无关。与 25-29 岁生育第一胎的男性相比，35-45 岁生育第一胎的男性酒精相关发病率和死亡率较低（风险比（HR）=0.57，95%置信区间（CI）=0.43，0.75）。所有父亲中，首次生育年龄在 20 岁以下的男性发病率和死亡率最高（HR=1.36，95%CI=1.09，1.69），其次是首次生育年龄在 20-24 岁的男性（HR=1.12，95%CI=1.00，1.25）。
研究结果表明，男性首次生育年龄与与酒精相关的发病率和死亡率之间的负相关关系不是由家族特征驱动的。
