Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Department of Nursing, Osaka City University Hospital, Osaka, Japan.
Int J Urol. 2020 May;27(5):408-414. doi: 10.1111/iju.14208. Epub 2020 Mar 7.
To investigate the prevalence of frailty, and the relationship of frailty based on the Kihon Checklist criteria with dialysis duration before transplantation and time after transplantation in kidney transplant recipients.
This study was a single-center, cross-sectional investigation carried out on kidney transplant recipients. To examine the association between the total Kihon Checklist score with time after transplant and dialysis duration before transplant, the multivariable proportional odds logistic regression model was used with adjustment for age, sex, body mass index, estimated glomerular filtration rate and serum albumin levels.
Out of 205 kidney transplant recipients enrolled in this study, frail, prefrail and robust recipients accounted for 11.2%, 26.8% and 62.0%, respectively. Dialysis duration before transplantation was associated with frailty, but time after transplant was not associated with frailty.
The prevalence of frailty in kidney transplant recipients is approximately 11%, and it is associated with the duration of pretransplant dialysis. These findings suggest that a shorter dialysis duration might be beneficial for preventing frailty in kidney transplant recipients.
调查肾移植受者虚弱的流行情况，并基于 Kihon Checklist 标准评估的虚弱与移植前透析时间和移植后时间之间的关系。
本研究为单中心横断面研究，纳入了肾移植受者。为了检验 Kihon Checklist 总分与移植后时间和移植前透析时间之间的关联，采用多变量比例优势逻辑回归模型进行分析，并对年龄、性别、体重指数、估算肾小球滤过率和血清白蛋白水平进行了调整。
在本研究纳入的 205 例肾移植受者中，虚弱、衰弱前期和健壮受者分别占 11.2%、26.8%和 62.0%。移植前透析时间与虚弱相关，但移植后时间与虚弱无关。
肾移植受者虚弱的流行率约为 11%，与移植前透析时间相关。这些发现提示，缩短透析时间可能有益于预防肾移植受者的虚弱。
