Department of Radiation Medical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Physics Department, Imam Khomeini International University, Qazvin, Iran.
Z Med Phys. 2020 Aug;30(3):185-193. doi: 10.1016/j.zemedi.2020.02.002. Epub 2020 Mar 4.
The present study aimed to produce a new, less toxic, and cost-effective polymer gel dosimeter using potassium salt of 2-acrylamido-2 methyl-propane sulfonic acid (AMPS) monomer. The new formulation was called PAKAG. The irradiation of PAKAG polymer gel dosimeter was performed using a 6 MV clinical linear accelerator, and its response was evaluated using magnetic resonance imaging. The obtained images were post-processed to produce related R maps. Afterward, the Dose-R calibration curves were obtained. Response dependence on the imaging temperature was examined. Furthermore, response stability over time was investigated. To investigate the radiological characteristics, the elemental composition, effective atomic number, electron density, and photon attenuation coefficient of PAKAG polymer gel dosimeter were calculated. A maximum sensitivity of 0.152±0.007 with the goodness of fit of R=0.999 in a dynamic range of 0-6Gy at 12h post-irradiation time was found. Such as other polymer gel dosimeter, the response of PAKAG polymer gel dosimeter was dependent on post-irradiation time and imaging temperature. Finally, it was concluded that the PAKAG polymer gel dosimeter could be used as a less toxic and cost-effective polymer gel dosimeter.
本研究旨在利用 2-丙烯酰胺-2-甲基丙磺酸（AMPS）单体的钾盐制备一种新型的、毒性更低且更具成本效益的聚合物凝胶剂量计。新配方称为 PAKAG。使用 6MV 临床直线加速器对 PAKAG 聚合物凝胶剂量计进行辐照，并使用磁共振成像评估其响应。对获得的图像进行后处理以生成相关的 R 映射。然后，获得剂量-响应校准曲线。检查了成像温度对响应的依赖性。此外，还研究了随时间的响应稳定性。为了研究放射学特性，计算了 PAKAG 聚合物凝胶剂量计的元素组成、有效原子数、电子密度和光子衰减系数。在辐照后 12 小时的动态范围内为 0-6Gy，发现最大灵敏度为 0.152±0.007，拟合优度 R=0.999。与其他聚合物凝胶剂量计一样，PAKAG 聚合物凝胶剂量计的响应依赖于辐照后时间和成像温度。最后得出结论，PAKAG 聚合物凝胶剂量计可用作毒性更低且更具成本效益的聚合物凝胶剂量计。
